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    Discovery of the natural anti-Gal antibody and its past and future relevance to medicine

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    Authors
    Galili, Uri
    UMass Chan Affiliations
    Department of Surgery
    Document Type
    Journal Article
    Publication Date
    2013-05-01
    Keywords
    Transplantation, Heterologous
    Amino Acids, Peptides, and Proteins
    Biochemistry
    Immunopathology
    Surgery
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1111/xen.12034
    Abstract
    This is a personal account of the discovery of the natural anti-Gal antibody, the most abundant natural antibody in humans, the reciprocal distribution of this antibody and its ligand the alpha-gal epitope in mammals and the immunological barrier this antibody has formed in porcine to human xenotransplantation. This barrier has been overcome in the recent decade with the generation of alpha1,3-galactosyltransferase gene-knockout pigs. However, anti-Gal continues to be relevant in medicine as it can be harnessed for various therapeutic effects. Anti-Gal converts tumor lesions injected with alpha-gal glycolipids into vaccines that elicit a protective anti-tumor immune response by in situ targeting of tumor cells for uptake by antigen-presenting cells. This antibody further accelerates wound and burn healing by interaction with alpha-gal nanoparticles applied to injured areas and induction of rapid recruitment and activation of macrophages. Anti-Gal/alpha-gal nanoparticle immune complexes may further induce rapid recruitment and activation of macrophages in ischemic myocardium and injured nerves, thereby inducing tissue regeneration and prevention of fibrosis.
    Source
    Xenotransplantation. 2013 May/June;20(3): 138–147. doi: 10.1111/xen.12034. Link to article on publisher's site
    DOI
    10.1111/xen.12034
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/30701
    PubMed ID
    23577774
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/xen.12034
    Scopus Count
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