Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing
Faust, Travis E.
Baer, Christina E.
Schafer, Dorothy P
Greer, Paul L.
UMass Chan AffiliationsSchafer Lab
Microbiology and Physiological Systems
Brudnick Neuropsychiatric Research Institute
Program in Bioinformatics and Integrative Biology
Program in Molecular Medicine
Document TypeJournal Article
MetadataShow full item record
AbstractThe olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerular positions in the mouse OB. These observations significantly extend earlier studies and suggest an overall organizational principle in the OB that may be used by the brain to assist in odor decoding.
Wang IH, Murray E, Andrews G, Jiang HC, Park SJ, Donnard E, Durán-Laforet V, Bear DM, Faust TE, Garber M, Baer CE, Schafer DP, Weng Z, Chen F, Macosko EZ, Greer PL. Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing. Nat Neurosci. 2022 Apr;25(4):484-492. doi: 10.1038/s41593-022-01030-8. Epub 2022 Mar 21. PMID: 35314823. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/30729
Full author list omitted for brevity. For the full list of authors, see article.