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dc.contributor.authorWang, I-Hao
dc.contributor.authorAndrews, Gregory
dc.contributor.authorDonnard, Elisa
dc.contributor.authorDuran-Laforet, Violeta
dc.contributor.authorFaust, Travis E.
dc.contributor.authorGarber, Manuel
dc.contributor.authorBaer, Christina E.
dc.contributor.authorSchafer, Dorothy P.
dc.contributor.authorWeng, Zhiping
dc.contributor.authorGreer, Paul L.
dc.date2022-08-11T08:08:34.000
dc.date.accessioned2022-08-23T15:59:42Z
dc.date.available2022-08-23T15:59:42Z
dc.date.issued2022-03-21
dc.date.submitted2022-05-05
dc.identifier.citation<p>Wang IH, Murray E, Andrews G, Jiang HC, Park SJ, Donnard E, Durán-Laforet V, Bear DM, Faust TE, Garber M, Baer CE, Schafer DP, Weng Z, Chen F, Macosko EZ, Greer PL. Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing. Nat Neurosci. 2022 Apr;25(4):484-492. doi: 10.1038/s41593-022-01030-8. Epub 2022 Mar 21. PMID: 35314823. <a href="https://doi.org/10.1038/s41593-022-01030-8">Link to article on publisher's site</a></p>
dc.identifier.issn1097-6256 (Linking)
dc.identifier.doi10.1038/s41593-022-01030-8
dc.identifier.pmid35314823
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30729
dc.description<p>Full author list omitted for brevity. For the full list of authors, see article.</p>
dc.description.abstractThe olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerular positions in the mouse OB. These observations significantly extend earlier studies and suggest an overall organizational principle in the OB that may be used by the brain to assist in odor decoding.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=35314823&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1038/s41593-022-01030-8
dc.subjectNeuroscience and Neurobiology
dc.titleSpatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing
dc.typeArticle
dc.source.journaltitleNature neuroscience
dc.source.volume25
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/faculty_pubs/2200
dc.identifier.contextkey29018207
html.description.abstract<p>The olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerular positions in the mouse OB. These observations significantly extend earlier studies and suggest an overall organizational principle in the OB that may be used by the brain to assist in odor decoding.</p>
dc.identifier.submissionpathfaculty_pubs/2200
dc.contributor.departmentSchafer Lab
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.contributor.departmentSanderson Center for Optical Imaging
dc.contributor.departmentBrudnick Neuropsychiatric Research Institute
dc.contributor.departmentDepartment of Neurobiology
dc.contributor.departmentProgram in Bioinformatics and Integrative Biology
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages484-492


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