Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila
Student Authors
Ye ShangFei Wang
Academic Program
NeuroscienceDocument Type
Journal ArticlePublication Date
2022-03-16Keywords
Drosophilaalternative splicing
nociception
nociceptive hypersensitivity
transient receptor potential (Trp)
Neuroscience and Neurobiology
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Show full item recordAbstract
Significance: Functional plasticity of the nociceptive circuit is a remarkable feature and is of clinical relevance. As an example, nociceptors lower their threshold upon tissue injury, a process known as allodynia that would facilitate healing by guarding the injured areas. However, long-lasting hypersensitivity could lead to chronic pain, a debilitating disease not effectively treated. Therefore, it is crucial to dissect the mechanisms underlying basal nociception and nociceptive hypersensitivity. In both vertebrate and invertebrate species, conserved transient receptor potential (Trp) channels are the primary transducers of noxious stimuli. Here, we provide a precedent that in Drosophila larvae, heat sensing in the nociception and hypersensitivity states is mediated by distinct heat-sensitive neurons and TrpA1 alternative isoforms.Source
Gu P, Wang F, Shang Y, Liu J, Gong J, Xie W, Han J, Xiang Y. Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2113645119. doi: 10.1073/pnas.2113645119. Epub 2022 Mar 16. PMID: 35294287; PMCID: PMC8944580. Link to article on publisher's site
DOI
10.1073/pnas.2113645119Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30733PubMed ID
35294287Related Resources
Rights
Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1073/pnas.2113645119
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Except where otherwise noted, this item's license is described as Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).