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Functional characterization of PKDREJ, a male germ cell-restricted polycystin

dc.contributor.authorSutton, Keith A.
dc.contributor.authorJungnickel, Melissa K.
dc.contributor.authorWard, Christopher J.
dc.contributor.authorHarris, Peter C.
dc.contributor.authorFlorman, Harvey M.
dc.date2022-08-11T08:08:34.000
dc.date.accessioned2022-08-23T15:59:54Z
dc.date.available2022-08-23T15:59:54Z
dc.date.issued2006-08-03
dc.date.submitted2011-03-23
dc.identifier.citationJ Cell Physiol. 2006 Nov;209(2):493-500. <a href="http://dx.doi.org/10.1002/jcp.20755">Link to article on publisher's site</a>
dc.identifier.issn0021-9541 (Linking)
dc.identifier.doi10.1002/jcp.20755
dc.identifier.pmid16883570
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30775
dc.description.abstractPolycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm. However, the functional characteristics of this protein and its role in sperm biology are not well understood. In this study it is shown that PKDREJ can modulate G protein signaling and associates with several members of the polycystin-2 family. These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16883570&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jcp.20755
dc.subjectAlternative Splicing
dc.subjectAmino Acid Sequence
dc.subjectCalcium Channels
dc.subjectCations
dc.subjectCells, Cultured
dc.subjectElectric Conductivity
dc.subjectG Protein-Coupled Inwardly-Rectifying Potassium Channels
dc.subjectGerm Cells
dc.subjectHumans
dc.subjectMale
dc.subjectMembrane Glycoproteins
dc.subjectMembrane Proteins
dc.subjectMolecular Sequence Data
dc.subjectPhosphoproteins
dc.subjectProtein Binding
dc.subjectReceptors, Cell Surface
dc.subjectTRPC Cation Channels
dc.subjectCell Biology
dc.titleFunctional characterization of PKDREJ, a male germ cell-restricted polycystin
dc.typeJournal Article
dc.source.journaltitleJournal of cellular physiology
dc.source.volume209
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/florman/5
dc.identifier.contextkey1895593
html.description.abstract<p>Polycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm. However, the functional characteristics of this protein and its role in sperm biology are not well understood. In this study it is shown that PKDREJ can modulate G protein signaling and associates with several members of the polycystin-2 family. These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology.</p>
dc.identifier.submissionpathflorman/5
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages493-500


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