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dc.contributor.authorLian, Min
dc.contributor.authorSchootman, Mario
dc.contributor.authorDoubeni, Chyke A.
dc.contributor.authorPark, Yikyung
dc.contributor.authorMajor, Jacqueline M.
dc.contributor.authorTorres Stone, Rosalie A.
dc.contributor.authorLaiyemo, Adeyinka O.
dc.contributor.authorHollenbeck, Albert R.
dc.contributor.authorGraubard, Barry I.
dc.contributor.authorSchatzkin, Arthur
dc.date2022-08-11T08:08:35.000
dc.date.accessioned2022-08-23T16:00:14Z
dc.date.available2022-08-23T16:00:14Z
dc.date.issued2011-08-11
dc.date.submitted2012-01-26
dc.identifier.citation<p>Am J Epidemiol. 2011 Oct 1;174(7):828-38. Epub 2011 Aug 11. <a href="http://dx.doi.org/10.1093/aje/kwr162">Link to article on publisher's site</a></p>
dc.identifier.issn0002-9262 (Linking)
dc.identifier.doi10.1093/aje/kwr162
dc.identifier.pmid21836166
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30838
dc.description.abstractAdverse socioeconomic conditions, at both the individual and the neighborhood level, increase the risk of colorectal cancer (CRC) death, but little is known regarding whether CRC survival varies geographically and the extent to which area-level socioeconomic deprivation affects this geographic variation. Using data from the National Institutes of Health (NIH)-AARP Diet and Health Study, the authors examined geographic variation and the role of area-level socioeconomic deprivation in CRC survival. CRC cases (n = 7,024), identified during 1995-2003, were followed for their CRC-specific vital status through 2005 and overall vital status through 2006. Bayesian multilevel survival models showed that there was significant geographic variation in overall (variance = 0.2, 95% confidence interval (CI): 0.1, 0.2) and CRC-specific (variance = 0.3, 95% CI: 0.1, 0.4) risk of death. More socioeconomically deprived neighborhoods had a higher overall risk of death (most deprived quartile vs. least deprived: hazard ratio = 1.2, 95% CI: 1.1, 1.4) and a higher CRC-specific risk of death (most deprived quartile vs. least deprived: hazard ratio = 1.2, 95% CI: 1.1, 1.5). However, neighborhood socioeconomic deprivation did not account for the geographic variation in overall and CRC-specific risks of death. In future studies, investigators should evaluate other neighborhood characteristics to help explain geographic heterogeneity in CRC survival. Such research could facilitate interventions for reducing geographic disparity in CRC survival.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21836166&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1093/aje/kwr162
dc.subjectAged
dc.subjectBayes Theorem
dc.subjectCause of Death
dc.subjectCohort Studies
dc.subjectColorectal Neoplasms
dc.subjectConsumer Organizations
dc.subjectFemale
dc.subjectGeography
dc.subject*Health Status Disparities
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNational Institutes of Health (U.S.)
dc.subjectPoverty
dc.subjectProspective Studies
dc.subjectQuestionnaires
dc.subjectRetirement
dc.subjectRisk Factors
dc.subjectSocioeconomic Factors
dc.subjectSurvival Analysis
dc.subjectUnemployment
dc.subjectUnited States
dc.subjectcohort studies
dc.subjectcolorectal neoplasms
dc.subjectgeography
dc.subjectmultilevel analysis
dc.subjectresidence characteristics
dc.subjectsocioeconomic factors
dc.subjectsurvival
dc.subjectCommunity Health and Preventive Medicine
dc.subjectDigestive System Diseases
dc.subjectInvestigative Techniques
dc.subjectNeoplasms
dc.subjectPathological Conditions, Signs and Symptoms
dc.subjectPreventive Medicine
dc.subjectPrimary Care
dc.titleGeographic variation in colorectal cancer survival and the role of small-area socioeconomic deprivation: a multilevel survival analysis of the NIH-AARP Diet and Health Study Cohort
dc.typeJournal Article
dc.source.journaltitleAmerican journal of epidemiology
dc.source.volume174
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/fmch_articles/167
dc.identifier.contextkey2472579
html.description.abstract<p>Adverse socioeconomic conditions, at both the individual and the neighborhood level, increase the risk of colorectal cancer (CRC) death, but little is known regarding whether CRC survival varies geographically and the extent to which area-level socioeconomic deprivation affects this geographic variation. Using data from the National Institutes of Health (NIH)-AARP Diet and Health Study, the authors examined geographic variation and the role of area-level socioeconomic deprivation in CRC survival. CRC cases (n = 7,024), identified during 1995-2003, were followed for their CRC-specific vital status through 2005 and overall vital status through 2006. Bayesian multilevel survival models showed that there was significant geographic variation in overall (variance = 0.2, 95% confidence interval (CI): 0.1, 0.2) and CRC-specific (variance = 0.3, 95% CI: 0.1, 0.4) risk of death. More socioeconomically deprived neighborhoods had a higher overall risk of death (most deprived quartile vs. least deprived: hazard ratio = 1.2, 95% CI: 1.1, 1.4) and a higher CRC-specific risk of death (most deprived quartile vs. least deprived: hazard ratio = 1.2, 95% CI: 1.1, 1.5). However, neighborhood socioeconomic deprivation did not account for the geographic variation in overall and CRC-specific risks of death. In future studies, investigators should evaluate other neighborhood characteristics to help explain geographic heterogeneity in CRC survival. Such research could facilitate interventions for reducing geographic disparity in CRC survival.</p>
dc.identifier.submissionpathfmch_articles/167
dc.contributor.departmentDepartment of Psychiatry
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Family Medicine and Community Health
dc.source.pages828-38


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