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dc.contributor.authorDiFranza, Joseph R.
dc.contributor.authorSavageau, Judith A.
dc.contributor.authorFletcher, Kenneth E.
dc.contributor.authorPbert, Lori
dc.contributor.authorO'Loughlin, Jennifer L.
dc.contributor.authorMcNeill, Ann D.
dc.contributor.authorOckene, Judith K.
dc.contributor.authorFriedman, Karen
dc.contributor.authorHazelton, Jennifer
dc.contributor.authorWood, Constance
dc.contributor.authorDussault, Gretchen
dc.contributor.authorWellman, Robert J.
dc.date2022-08-11T08:08:36.000
dc.date.accessioned2022-08-23T16:00:54Z
dc.date.available2022-08-23T16:00:54Z
dc.date.issued2007-10-01
dc.date.submitted2008-06-13
dc.identifier.citationPediatrics. 2007 Oct;120(4):e974-83. <a href="http://dx.doi.org/10.1542/peds.2007-0027">Link to article on publisher's site</a>
dc.identifier.issn1098-4275 (Electronic)
dc.identifier.doi10.1542/peds.2007-0027
dc.identifier.pmid17908753
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30991
dc.description.abstractOBJECTIVES: The purpose of this work was to identify characteristics that predict progression from the first inhalation of a cigarette to dependence. We studied a cohort of 1246 public school 6th-graders in 6 Massachusetts communities (mean age at baseline: 12.2 years). METHODS: We conducted a 4-year prospective study using 11 interviews. We assessed 45 risk factors and measured diminished autonomy over tobacco with the Hooked on Nicotine Checklist and evaluated tobacco dependence according to the International Classification of Diseases, 10th Revision. Cox proportional-hazards models were used. RESULTS: Among 217 youths who had inhaled from a cigarette, the loss of autonomy over tobacco was predicted by feeling relaxed the first time inhaling from a cigarette and depressed mood. Tobacco dependence was predicted by feeling relaxed, familiarity with Joe Camel, novelty seeking, and depressed mood. CONCLUSIONS: Once exposure to nicotine had occurred, remarkably few risk factors for smoking consistently contributed to individual differences in susceptibility to the development of dependence or loss of autonomy. An experience of relaxation in response to the first dose of nicotine was the strongest predictor of both dependence and lost autonomy. This association was not explained by trait anxiety or any of the other measured psychosocial factors. These results are discussed in relation to the theory that the process of dependence is initiated by the first dose of nicotine.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17908753&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1542/peds.2007-0027
dc.subjectAdolescent
dc.subjectAdolescent Behavior
dc.subjectAdvertising as Topic
dc.subjectChild
dc.subjectDepression
dc.subjectDisease Susceptibility
dc.subjectExploratory Behavior
dc.subjectFemale
dc.subjectHumans
dc.subjectInterviews as Topic
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectPersonal Autonomy
dc.subjectProportional Hazards Models
dc.subjectProspective Studies
dc.subjectRelaxation
dc.subjectTobacco Use Disorder
dc.subjectCommunity Health
dc.subjectOther Medical Specialties
dc.subjectPreventive Medicine
dc.titleSusceptibility to nicotine dependence: the Development and Assessment of Nicotine Dependence in Youth 2 study
dc.typeJournal Article
dc.source.journaltitlePediatrics
dc.source.volume120
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/fmch_articles/47
dc.identifier.contextkey525896
html.description.abstract<p>OBJECTIVES: The purpose of this work was to identify characteristics that predict progression from the first inhalation of a cigarette to dependence. We studied a cohort of 1246 public school 6th-graders in 6 Massachusetts communities (mean age at baseline: 12.2 years).</p> <p>METHODS: We conducted a 4-year prospective study using 11 interviews. We assessed 45 risk factors and measured diminished autonomy over tobacco with the Hooked on Nicotine Checklist and evaluated tobacco dependence according to the International Classification of Diseases, 10th Revision. Cox proportional-hazards models were used.</p> <p>RESULTS: Among 217 youths who had inhaled from a cigarette, the loss of autonomy over tobacco was predicted by feeling relaxed the first time inhaling from a cigarette and depressed mood. Tobacco dependence was predicted by feeling relaxed, familiarity with Joe Camel, novelty seeking, and depressed mood.</p> <p>CONCLUSIONS: Once exposure to nicotine had occurred, remarkably few risk factors for smoking consistently contributed to individual differences in susceptibility to the development of dependence or loss of autonomy. An experience of relaxation in response to the first dose of nicotine was the strongest predictor of both dependence and lost autonomy. This association was not explained by trait anxiety or any of the other measured psychosocial factors. These results are discussed in relation to the theory that the process of dependence is initiated by the first dose of nicotine.</p>
dc.identifier.submissionpathfmch_articles/47
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.contributor.departmentDepartment of Psychiatry
dc.contributor.departmentDepartment of Family Medicine and Community Health
dc.source.pagese974-83


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