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dc.contributor.authorDiFranza, Joseph R.
dc.contributor.authorSavageau, Judith A.
dc.contributor.authorFletcher, Kenneth E.
dc.contributor.authorO'Loughlin, Jennifer L.
dc.contributor.authorPbert, Lori
dc.contributor.authorOckene, Judith K.
dc.contributor.authorMcNeill, Ann D.
dc.contributor.authorHazelton, Jennifer
dc.contributor.authorFriedman, Karen
dc.contributor.authorDussault, Gretchen
dc.contributor.authorWood, Constance
dc.contributor.authorWellman, Robert J.
dc.date2022-08-11T08:08:36.000
dc.date.accessioned2022-08-23T16:00:54Z
dc.date.available2022-08-23T16:00:54Z
dc.date.issued2007-07-01
dc.date.submitted2008-06-26
dc.identifier.citationArch Pediatr Adolesc Med. 2007 Jul;161(7):704-10. <a href="http://dx.doi.org/10.1001/archpedi.161.7.704">Link to article on publisher's site</a>
dc.identifier.issn1072-4710
dc.identifier.doi10.1001/archpedi.161.7.704
dc.identifier.pmid17606835
dc.identifier.urihttp://hdl.handle.net/20.500.14038/30992
dc.description.abstractOBJECTIVE: To extend the findings of the first Development and Assessment of Nicotine Dependence in Youth study by using diagnostic criteria for tobacco dependence and a biochemical measure of nicotine intake. The first study found that symptoms of dependence commonly appeared soon after the onset of intermittent smoking. DESIGN: A 4-year prospective study. SETTING: Public schools in 6 Massachusetts communities. PARTICIPANTS: A cohort of 1246 sixth-grade students. INTERVENTIONS: Eleven interviews. MAIN OUTCOME MEASURES: Loss of autonomy over tobacco as measured by the Hooked on Nicotine Checklist, and tobacco dependence as defined in International Classification of Diseases, 10th Revision (ICD-10). RESULTS: Among the 217 inhalers, 127 lost autonomy over their tobacco use, 10% having done so within 2 days and 25% having done so within 30 days of first inhaling from a cigarette; half had lost autonomy by the time they were smoking 7 cigarettes per month. Among the 83 inhalers who developed ICD-10-defined dependence, half had done so by the time they were smoking 46 cigarettes per month. At the interview following the onset of ICD-10-defined dependence, the median salivary cotinine concentration of current smokers was 5.35 ng/mL, a level that falls well below the cutoff used to distinguish active from passive smokers. CONCLUSIONS: The most susceptible youths lose autonomy over tobacco within a day or 2 of first inhaling from a cigarette. The appearance of tobacco withdrawal symptoms and failed attempts at cessation can precede daily smoking; ICD-10-defined dependence can precede daily smoking and typically appears before consumption reaches 2 cigarettes per day.
dc.language.isoen_US
dc.publisherAmerican Medical Association
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17606835&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1001/archpedi.161.7.704
dc.subjectAdolescent
dc.subjectBehavior, Addictive
dc.subjectChild
dc.subjectCotinine
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectInternational Classification of Diseases
dc.subjectInterviews as Topic
dc.subjectMale
dc.subjectMassachusetts
dc.subjectPersonal Autonomy
dc.subjectProspective Studies
dc.subjectPsychological Tests
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectSaliva
dc.subjectSchools
dc.subjectSmoking
dc.subjectSmoking Cessation
dc.subjectStudents
dc.subjectTime Factors
dc.subjectTobacco Use Disorder
dc.subjectCommunity Health
dc.subjectOther Medical Specialties
dc.subjectPreventive Medicine
dc.titleSymptoms of tobacco dependence after brief intermittent use: the Development and Assessment of Nicotine Dependence in Youth-2 study.
dc.typeJournal Article
dc.source.journaltitleArchives of pediatrics & adolescent medicine
dc.source.volume161
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/fmch_articles/48
dc.identifier.contextkey539177
html.description.abstract<p>OBJECTIVE: To extend the findings of the first Development and Assessment of Nicotine Dependence in Youth study by using diagnostic criteria for tobacco dependence and a biochemical measure of nicotine intake. The first study found that symptoms of dependence commonly appeared soon after the onset of intermittent smoking.</p> <p>DESIGN: A 4-year prospective study.</p> <p>SETTING: Public schools in 6 Massachusetts communities.</p> <p>PARTICIPANTS: A cohort of 1246 sixth-grade students.</p> <p>INTERVENTIONS: Eleven interviews.</p> <p>MAIN OUTCOME MEASURES: Loss of autonomy over tobacco as measured by the Hooked on Nicotine Checklist, and tobacco dependence as defined in International Classification of Diseases, 10th Revision (ICD-10).</p> <p>RESULTS: Among the 217 inhalers, 127 lost autonomy over their tobacco use, 10% having done so within 2 days and 25% having done so within 30 days of first inhaling from a cigarette; half had lost autonomy by the time they were smoking 7 cigarettes per month. Among the 83 inhalers who developed ICD-10-defined dependence, half had done so by the time they were smoking 46 cigarettes per month. At the interview following the onset of ICD-10-defined dependence, the median salivary cotinine concentration of current smokers was 5.35 ng/mL, a level that falls well below the cutoff used to distinguish active from passive smokers.</p> <p>CONCLUSIONS: The most susceptible youths lose autonomy over tobacco within a day or 2 of first inhaling from a cigarette. The appearance of tobacco withdrawal symptoms and failed attempts at cessation can precede daily smoking; ICD-10-defined dependence can precede daily smoking and typically appears before consumption reaches 2 cigarettes per day.</p>
dc.identifier.submissionpathfmch_articles/48
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.contributor.departmentDepartment of Psychiatry
dc.contributor.departmentDepartment of Family Medicine and Community Health


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