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    Molecular hepatic carcinogenesis: impact of inflammation

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    Authors
    Szabo, Gyongyi
    Lippai, Dora
    UMass Chan Affiliations
    Department of Medicine, Division of Gastroenterology
    Document Type
    Journal Article
    Publication Date
    2012-06-01
    Keywords
    Carcinoma, Hepatocellular
    Inflammation
    Digestive System Diseases
    Gastroenterology
    Hepatology
    Immunology and Infectious Disease
    Neoplasms
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1159/000336913
    Abstract
    Hepatocellular cancer (HCC) represents one of the most rapidly spreading cancers in the world. Most HCC develops in cirrhotic livers after prolonged inflammation, supporting the hypothesis that inflammation contributes to cancer development. Increasing evidence suggests that inflammatory cell recruitment and activation is an important contributor to promoting cancerous malformation in hepatocytes. Intracellular signaling pathways involved in classical inflammatory pathway activation can be altered in parenchymal cells, hepatocytes, in the liver to promote HCC development. Inflammation is triggered by pathogen-derived or endogenous danger-associated molecular patterns via pattern recognition receptors. Activation of the pattern recognition receptors triggers downstream signaling cascades to induce proinflammatory cytokine production, release of reactive oxygen species and modulate cellular responses. Many of these inflammatory mediators have adverse effects on DNA repair and induce DNA methylation, both of which are important elements in HCC development. This review summarizes the key points and discusses recent findings related to the role of inflammation in cancer and HCC development.
    Source

    Dig Dis. 2012;30(3):243-8. Epub 2012 Jun 20. Link to article on publisher's site

    DOI
    10.1159/000336913
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/31059
    PubMed ID
    22722548
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1159/000336913
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