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dc.contributor.authorSaha, Banishree
dc.contributor.authorSzabo, Gyongyi
dc.date2022-08-11T08:08:37.000
dc.date.accessioned2022-08-23T16:01:14Z
dc.date.available2022-08-23T16:01:14Z
dc.date.issued2014-07-07
dc.date.submitted2014-09-11
dc.identifier.citationJ Leukoc Biol. 2014 Jul 7. doi:10.1189/jlb.4MR0314-141R <a href="http://dx.doi.org/10.1189/jlb.4MR0314-141R">Link to article on publisher's site</a>
dc.identifier.issn0741-5400 (Linking)
dc.identifier.doi10.1189/jlb.4MR0314-141R
dc.identifier.pmid25001860
dc.identifier.urihttp://hdl.handle.net/20.500.14038/31072
dc.description.abstractPersistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the interactive network of immune cells as a whole acts against the virus. The innate immune system forms the first line of host defense against viral infection, and thus, virus elimination or chronic HCV infection is linked to the direct outcome of the interactions between the various innate immune cells and HCV. By understanding how the distinct components of the innate immune system function both individually and collectively during HCV infection, potential therapeutic targets can be identified to overcome immune dysfunction and control chronic viral infection.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25001860&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/doi:10.1189/jlb.4MR0314-141R
dc.subjectDigestive System Diseases
dc.subjectGastroenterology
dc.subjectHepatology
dc.subjectImmunology of Infectious Disease
dc.subjectImmunopathology
dc.titleInnate immune cell networking in hepatitis C virus infection
dc.typeJournal Article
dc.source.journaltitleJournal of leukocyte biology
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gastroenterology_pp/129
dc.identifier.contextkey6105454
html.description.abstract<p>Persistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the interactive network of immune cells as a whole acts against the virus. The innate immune system forms the first line of host defense against viral infection, and thus, virus elimination or chronic HCV infection is linked to the direct outcome of the interactions between the various innate immune cells and HCV. By understanding how the distinct components of the innate immune system function both individually and collectively during HCV infection, potential therapeutic targets can be identified to overcome immune dysfunction and control chronic viral infection.</p>
dc.identifier.submissionpathgastroenterology_pp/129
dc.contributor.departmentDepartment of Medicine, Division of Gastroenterology


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