Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis
UMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
2013-08-01Keywords
BacteriaFatty Liver
Fatty Liver, Alcoholic
Humans
Immunity, Innate
Inflammasomes
Interleukin-1
Intestines
Lipopolysaccharides
Risk Factors
Signal Transduction
Toll-Like Receptor 4
Digestive System Diseases
Gastroenterology
Hepatology
Immunopathology
Metadata
Show full item recordAbstract
The similar histopathological characteristics of alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH), and the crucial role of the innate immune response in both conditions may lead to the assumption that ASH and NASH represent the same pathophysiological entities caused by different risk factors. In this review paper, we elaborate on the pathophysiological differences between these two entities and highlight the disease-specific involvement of signaling molecules downstream of the Toll-like receptor 4, and the differential mechanism by which the inflammasome contributes to ASH versus NASH. Our findings emphasize that ASH and NASH have disease-specific mechanisms and therefore represent distinct biological entities. Further studies are needed to dissect the emerging differences in pathogenesis of these two conditions. Publishing Asia Pty Ltd.Source
J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:93-8. doi: 10.1111/jgh.12020. Link to article on publisher's siteDOI
10.1111/jgh.12020Permanent Link to this Item
http://hdl.handle.net/20.500.14038/31081PubMed ID
23855302Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1111/jgh.12020