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    Binge ethanol and liver: new molecular developments

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    Authors
    Shukla, Shivendra D.
    Pruett, Stephen B.
    Szabo, Gyongyi
    Arteel, Gavin E.
    UMass Chan Affiliations
    Department of Medicine, Division of Gastroenterology
    Document Type
    Journal Article
    Publication Date
    2013-04-01
    Keywords
    Animals
    Binge Drinking
    Ethanol
    Humans
    Inflammation Mediators
    Liver
    Liver Diseases, Alcoholic
    Digestive System Diseases
    Gastroenterology
    Hepatology
    Substance Abuse and Addiction
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    Link to Full Text
    http://dx.doi.org/10.1111/acer.12011
    Abstract
    Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.
    Source
    Alcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24. Link to article on publisher's site
    DOI
    10.1111/acer.12011
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/31083
    PubMed ID
    23347137
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/acer.12011
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