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Binge ethanol and liver: new molecular developments

dc.contributor.authorShukla, Shivendra D.
dc.contributor.authorPruett, Stephen B.
dc.contributor.authorSzabo, Gyongyi
dc.contributor.authorArteel, Gavin E.
dc.date2022-08-11T08:08:37.000
dc.date.accessioned2022-08-23T16:01:17Z
dc.date.available2022-08-23T16:01:17Z
dc.date.issued2013-04-01
dc.date.submitted2014-09-11
dc.identifier.citationAlcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24. <a href="http://dx.doi.org/10.1111/acer.12011">Link to article on publisher's site</a>
dc.identifier.issn0145-6008 (Linking)
dc.identifier.doi10.1111/acer.12011
dc.identifier.pmid23347137
dc.identifier.urihttp://hdl.handle.net/20.500.14038/31083
dc.description.abstractBinge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23347137&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1111/acer.12011
dc.subjectAnimals
dc.subjectBinge Drinking
dc.subjectEthanol
dc.subjectHumans
dc.subjectInflammation Mediators
dc.subjectLiver
dc.subjectLiver Diseases, Alcoholic
dc.subjectDigestive System Diseases
dc.subjectGastroenterology
dc.subjectHepatology
dc.subjectSubstance Abuse and Addiction
dc.titleBinge ethanol and liver: new molecular developments
dc.typeJournal Article
dc.source.journaltitleAlcoholism, clinical and experimental research
dc.source.volume37
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gastroenterology_pp/139
dc.identifier.contextkey6105465
html.description.abstract<p>Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.</p>
dc.identifier.submissionpathgastroenterology_pp/139
dc.contributor.departmentDepartment of Medicine, Division of Gastroenterology
dc.source.pages550-7


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