Authors
Szabo, GyongyiUMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
1998-09-04Keywords
AdultAlcohol Drinking
Alcoholic Intoxication
Ethanol
Female
Humans
Immune Tolerance
Interferon-gamma
Interleukin-1
Lipopolysaccharides
Male
Middle Aged
Monocytes
Gastroenterology
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
The immunomodulatory capacity of acute, moderate alcohol consumption was investigated in this study in nonalcoholic volunteers after 2 ml of vodka/kg body weight of alcohol consumption. There was a significant, transient increase in interleukin-12 and interferon-gamma (IFNgamma) levels in whole blood samples collected 4 hr after alcohol consumption in response to an ex vivo bacterial challenge with lipopolysaccharide (p < 0.02). However, decreased IFNgamma levels were produced by mononuclear cells collected later after alcohol consumption (16 hr), suggesting that acute alcohol consumption has a biphasic effect on IFNgamma inducibility. Furthermore, isolated blood monocytes collected 16 hr after alcohol consumption showed significantly decreased IL-1beta production in response to subsequent bacterial stimulation, implying that in vivo alcohol consumption affects monocyte-derived inflammatory cytokine production. These results demonstrate that even acute, moderate alcohol consumption has a modulating capacity on immune functions that may contribute to decreased immunity and host defense.Source
Alcohol Clin Exp Res. 1998 Aug;22(5 Suppl):216S-219S.
DOI
10.1097/00000374-199805001-00002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/31099PubMed ID
9727639Related Resources
ae974a485f413a2113503eed53cd6c53
10.1097/00000374-199805001-00002