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    Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity

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    Authors
    Szabo, Gyongyi
    Aloman, Costica
    Polyak, Stephen J.
    Weinman, Steven A.
    Wands, Jack
    Zakhari, Samir
    UMass Chan Affiliations
    Department of Medicine, Division of Gastroenterology
    Document Type
    Journal Article
    Publication Date
    2006-04-01
    Keywords
    Alcoholism
    Animals
    Antibody Formation
    Dendritic Cells
    Ethanol
    Hepacivirus
    Hepatitis C
    Humans
    *Immunity
    Immunity, Cellular
    Liver Diseases
    Mitochondria, Liver
    Signal Transduction
    Viral Proteins
    Virus Replication
    Gastroenterology
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    Link to Full Text
    http://dx.doi.org/10.1111/j.1530-0277.2006.00083.x
    Abstract
    This article presents the proceedings of a symposium presented at the meeting of the Research Society on Alcoholism, held in Santa Barbara, California, in June 2005. The organizers and chairs were Sam Zakhari and Gyongyi Szabo. The presentations included (1) Mitochondrial Abnormalities Induced by Hepatitis C -Alcohol Interaction by Steven Weinman; (2) Effects of Acute and Chronic Ethanol on Innate Antiviral Signaling Pathways, Hepatitis C Replication, and Human Liver Cell Transcription by Stephen Polyak; (3) Ethanol Alters Dendritic Cell Function In Vivo and Impairs the Subsequent Cellular Immune Responses to Hepatitis C Proteins by Costica Aloman; and (4) Pathogenic Interactions Between Hepatitis C Virus and Alcohol Use in Humans: Dendritic Cells as Common Targets by Gyongyi Szabo. This symposium summarizes the state of knowledge of cellular and molecular pathways by which alcohol and HCV have pathogenic interactions resulting in depression of the immune response and liver damage in chronic HCV infection.
    Source
    Alcohol Clin Exp Res. 2006 Apr;30(4):709-19. Link to article on publisher's site
    DOI
    10.1111/j.1530-0277.2006.00083.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/31124
    PubMed ID
    16573590
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1530-0277.2006.00083.x
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