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dc.contributor.advisorMilagros C. Rosal
dc.contributor.authorLópez-Cepero, Andrea A
dc.date2022-08-11T08:08:38.000
dc.date.accessioned2022-08-23T16:01:52Z
dc.date.available2022-08-23T16:01:52Z
dc.date.issued2019-03-29
dc.date.submitted2019-04-18
dc.identifier.doi10.13028/6y2r-6f43
dc.identifier.urihttp://hdl.handle.net/20.500.14038/31230
dc.description.abstractBackground: Puerto Ricans experience high prevalence of type 2 diabetes (diabetes). Stress is a risk factor for diabetes. The allostatic load (AL) model explains how stress influences disease through a chain of physiological changes. Puerto Ricans experience psychological and physiological (obesity and high glycemic load (GL)) stressors linked with diabetes, yet how these stressors impact the AL chain and how their interplay affects glucose metabolism remains unknown. Methods: Using data from the Boston Puerto Rican Health Study, this thesis sought to examine: 1) the relationship between GL and primary AL markers, 2) the interaction between perceived stress and GL on HbA1c, and if primary AL markers mediate this interaction, and 3) the interaction between change in weight and in perceived stress on HbA1c. Results: 1) GL change over 2 years was associated with increases in primary AL markers in women. 2) Women with high perceived stress and high GL had higher HbA1c and primary AL markers did not mediate this interaction. 3) In women, there was an interaction between change in weight and perceived stress on HbA1c over 2 years, with the effect of weight change on HbA1c being greater with increases in perceived stress. None of these associations were observed in men. Conclusion: This study partially confirms the AL model in Puerto Rican women but not in men. It provides data to inform intervention targets to prevent and manage diabetes in Puerto Rican women and identifies women at high risk of diabetes in this minority group.
dc.language.isoen_US
dc.rightsCopyright is held by the author, with all rights reserved.
dc.subjectAllostatic load
dc.subjectglycemic load
dc.subjectperceived stress
dc.subjecttype 2 diabetes
dc.subjectPuerto Rican
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectHealth Psychology
dc.subjectPsychiatry and Psychology
dc.subjectPublic Health
dc.subjectSocial and Behavioral Sciences
dc.titlePhysiological and Psychological Stressors Associated with Glucose Metabolism in the Boston Puerto Rican Health Study
dc.typeDoctoral Dissertation
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2022&context=gsbs_diss&unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_diss/1012
dc.legacy.embargo2020-04-19T00:00:00-07:00
dc.identifier.contextkey14298913
refterms.dateFOA2022-08-25T04:30:13Z
html.description.abstract<p><strong>Background: </strong>Puerto Ricans experience high prevalence of type 2 diabetes (diabetes). Stress is a risk factor for diabetes. The allostatic load (AL) model explains how stress influences disease through a chain of physiological changes. Puerto Ricans experience psychological and physiological (obesity and high glycemic load (GL)) stressors linked with diabetes, yet how these stressors impact the AL chain and how their interplay affects glucose metabolism remains unknown.</p> <p><strong>Methods</strong>: Using data from the Boston Puerto Rican Health Study, this thesis sought to examine: 1) the relationship between GL and primary AL markers, 2) the interaction between perceived stress and GL on HbA1c, and if primary AL markers mediate this interaction, and 3) the interaction between change in weight and in perceived stress on HbA1c.</p> <p><strong>Results</strong>: 1) GL change over 2 years was associated with increases in primary AL markers in women. 2) Women with high perceived stress and high GL had higher HbA1c and primary AL markers did not mediate this interaction. 3) In women, there was an interaction between change in weight and perceived stress on HbA1c over 2 years, with the effect of weight change on HbA1c being greater with increases in perceived stress. None of these associations were observed in men.</p> <p><strong>Conclusion</strong>: This study partially confirms the AL model in Puerto Rican women but not in men. It provides data to inform intervention targets to prevent and manage diabetes in Puerto Rican women and identifies women at high risk of diabetes in this minority group.</p>
dc.identifier.submissionpathgsbs_diss/1012
dc.contributor.departmentQuantitative Health Sciences
dc.description.thesisprogramClinical and Population Health Research
dc.identifier.orcid0000-0001-7238-1269


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