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dc.contributor.authorSimon, Claude Demosthene
dc.date2022-08-11T08:08:40.000
dc.date.accessioned2022-08-23T16:03:53Z
dc.date.available2022-08-23T16:03:53Z
dc.date.issued1988-12-01
dc.date.submitted2007-03-13
dc.identifier.urihttp://hdl.handle.net/20.500.14038/31571
dc.descriptionIn the process of seeking author's permission to provide full text.
dc.description.abstractThe mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
dc.language.isoen_US
dc.rightsCopyright is held by the author, with all rights reserved.
dc.subjectGrowth Hormone
dc.subjectBlood Pressure
dc.subjectRenin
dc.subjectRenin-Angiotensin System
dc.subjectRats
dc.subjectAcademic Dissertations
dc.subjectDissertations, UMMS
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleInteractions between Growth Hormone and the Mechanisms Controlling Arterial Pressure and Renin Secretion in the Rat: A Thesis
dc.typeDoctoral Dissertation
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_diss/261
dc.legacy.embargo2017-04-24T00:00:00-07:00
dc.identifier.contextkey271906
html.description.abstract<p>The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.</p>
dc.identifier.submissionpathgsbs_diss/261
dc.contributor.departmentGraduate School of Biomedical Sciences, Physiology


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