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    Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation

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    Authors
    Huang, Tingting
    Faculty Advisor
    Jaime Rivera Perez, PhD
    Academic Program
    Cell Biology
    UMass Chan Affiliations
    Pediatrics
    Document Type
    Doctoral Dissertation
    Publication Date
    2014-02-28
    Keywords
    Dissertations, UMMS
    Mice
    Endoderm
    Body Patterning
    Embryonic Development
    Mice
    Endoderm
    Body Patterning
    Embryonic Development
    Cellular and Molecular Physiology
    Developmental Biology
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    Abstract
    Early post-implantation vertebrate embryos are shaped by complex cellular and molecular mechanisms. In mice, the visceral endoderm, an extraembryonic cell lineage that appears before gastrulation, provides several important functions such as nutrition and mechanical protection. My thesis research focused on the role of the visceral endoderm in embryo patterning, a newly discovered function for this tissue. My results showed that an interplay between two subpopulations of visceral endoderm the anterior and posterior visceral endoderm, located on the opposite sides of the developing conceptus, are critical for the establishment of the anteroposterior body axis of the embryo. I also found that senescence-associated β-galactosidase activity delineates the visceral endoderm marking apical vacuole, a lysosomal-like organelle. This however indicates the nutritional function of visceral endoderm cells rather than a senescent population. My studies highlight the fundamental role of extraembryonic tissues in patterning mammalian embryos as opposed to housekeeping roles. They also reveal important difference when conducting studies at the organismal level rather than in cells in culture.
    DOI
    10.13028/M26G63
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32050
    Rights
    Copyright is held by the author, with all rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.13028/M26G63
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    Morningside Graduate School of Biomedical Sciences Dissertations and Theses

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