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    Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward

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    Authors
    Derner, Melissa Guildford
    Faculty Advisor
    Andrew R. Tapper
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Tapper Lab
    Psychiatry
    Document Type
    Doctoral Dissertation; Doctoral Dissertation
    Publication Date
    2016-12-08
    Keywords
    Alcohol
    dopamine
    mice
    nicotinic acetylcholine receptor
    reward
    behavior
    sex difference
    VTA
    CPP
    DID c-Fos
    Behavioral Neurobiology
    Molecular and Cellular Neuroscience
    Neuroscience and Neurobiology
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    Abstract
    Alcohol, recently named the most dangerous drug in the world, contributes to nearly 40% of violent crimes and fatal traffic accidents, increases risk of roughly 60 different diseases and injuries, and is responsible for 2.5 million deaths each year worldwide. Despite these staggering figures, treatments remain ineffective and riddled with adverse side effects, making successful use of even the most effective treatments unlikely. Moreover, many of the treatments, and the supporting research, have focused only on male subjects, despite sex differences in various alcohol-related behaviors. Human alcohol use is frequently accompanied by nicotine use, and vice versa, suggesting a common mechanism of the two drugs. In fact, alcohol may act through the same family of receptors as nicotine, the nicotinic acetylcholine receptors (nAChRs), eliciting similar activation of the reward pathway as nicotine and other drugs of abuse. Studies have shown that nAChRs containing the α4 and/or α6 subunits are involved in nicotine-induced activation of the reward pathway, leading to the hypothesis that these same receptor subtypes may be important for alcohol effects in the brain as well. Using male and female genetic mouse models and various behavioral assays, we have shown not only that these α4 and/or α6-containing nAChRs are involved in alcohol- related behaviors and activation of the reward pathway, but also show sex differences in this involvement. Uncovering the mechanism of alcohol in the brain, in males as well as in females, is an important step in developing targeted treatments for alcohol abuse.
    DOI
    10.13028/M2C88B
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32265
    Rights
    Copyright is held by the author, with all rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.13028/M2C88B
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