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    Clostridium difficile Colonization and Infection in the Elderly and Associations with the Aging Intestinal Microbiome

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    Authors
    Haran, John P.
    Faculty Advisor
    Beth McCormick
    Academic Program
    Millennium PhD
    UMass Chan Affiliations
    Emergency Medicine, Microbiology and Physiological Systems
    Document Type
    Doctoral Dissertation
    Publication Date
    2018-03-14
    Keywords
    Elderly
    Microbiome
    Clostridium difficile
    colonization
    infection
    medications
    Digestive System Diseases
    Geriatrics
    Infectious Disease
    
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    Abstract
    The widespread use of antibiotics has led to dramatic increases in the incidence and severity of Clostridium difficile infection (CDI). No group of patients suffers more from CDI than the elderly. Nursing homes (NH) represent the perfect storm of a vulnerable group of frail elders living in confined communities. Nursing home residents suffer from increased morbidity and mortality from CDI and corresponding high rates of C. difficile colonization. Upwards of 40 to 50% of CDI current cases originate from NHs and the prevalence of colonization rates remain high within these facilities, with as many as half of the residents being colonized with C. difficile at any given time. One factor that has become of increasing interest and a target of preventive strategies is the human intestinal microbiome. A healthy, diverse microbiome interacts with the host immune system and contributes to pathogen resistance. In this investigation, we first examine elder specific variables to determine if the associated risks of CDI differ by home living environment (nursing home versus community-dwelling). We then go on explore the relationships of NH environment, frailty, nutritional status, and residents’ age with microbiome composition and potential metabolic function. Finally, we describe the C. difficile colonization patterns among elderly NH residents and the associated risk of colonization based on clinical variables and microbiome determinants. A better understanding of the microbiome’s contribution to C. difficile colonization will provide the basis for informing rational interventions and public health policies to better combat CDI in the nursing home.
    DOI
    10.13028/M2NQ4S
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32361
    Rights
    Copyright is held by the author, with all rights reserved.
    ae974a485f413a2113503eed53cd6c53
    10.13028/M2NQ4S
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    Morningside Graduate School of Biomedical Sciences Dissertations and Theses

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