• Login
    View Item 
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside GSBS Scholarly Publications
    • View Item
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside GSBS Scholarly Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingUsage StatisticsAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Kruger, Annie J.
    Yang, Chaoxing
    Lipson, Kathryn L.
    Pino, Steven C.
    Leif, Jean H.
    Hogan, Christopher M.
    Whalen, Barbara J.
    Guberski, Dennis L L.
    Lee, Young
    Unger, Roger H.
    Greiner, Dale L.
    Rossini, Aldo A.
    Bortell, Rita
    Show allShow less
    Student Authors
    Annie J. Kruger
    UMass Chan Affiliations
    Department of Medicine, Division of Diabetes
    Graduate School of Biomedical Sciences, MD/PhD Program
    Document Type
    Journal Article
    Publication Date
    2010-08-09
    Keywords
    Diabetes Mellitus, Type 1
    Leptin
    Rats, Inbred BB
    Islets of Langerhans Transplantation
    Nutritional and Metabolic Diseases
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.3109/08916934.2010.482116
    Abstract
    The adipokine, leptin, regulates blood glucose and the insulin secretory function of beta cells, while also modulating immune cell function. We hypothesized that the dual effects of leptin may prevent or suppress the autoreactive destruction of beta cells in a virally induced rodent model of type 1 diabetes. Nearly 100% of weanling BBDR rats treated with the combination of an innate immune system activator, polyinosinic:polycytidylic acid (pIC), and Kilham rat virus (KRV) become diabetic within a predictable time frame. We utilized this model to test the efficacy of leptin in preventing diabetes onset, remitting new onset disease, and preventing autoimmune recurrence in diabetic rats transplanted with syngeneic islet grafts. High doses of leptin delivered via an adenovirus vector (AdLeptin) or alzet pump prevented diabetes in>90% of rats treated with pIC+KRV. The serum hyperleptinemia generated by this treatment was associated with decreased body weight, decreased non-fasting serum insulin levels, and lack of islet insulitis in leptin-treated rats. In new onset diabetics, hyperleptinemia prevented rapid weight loss and diabetic ketoacidosis, and temporarily restored euglycemia. Leptin treatment also prolonged the survival of syngeneic islets transplanted into diabetic BBDR rats. In diverse therapeutic settings, we found leptin treatment to have significant beneficial effects in modulating virally induced diabetes. These findings merit further evaluation of leptin as a potential adjunct therapeutic agent for treatment of human type 1 diabetes.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32419
    PubMed ID
    20695765
    Related Resources
    Link to article in PubMed
    Rights
    Citation: Autoimmunity. 2010 Aug 9. [Epub ahead of print]. doi:10.3109/08916934.2010.482116
    Collections
    Morningside GSBS Scholarly Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.