UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyGraduate School of Biomedical Sciences
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
1992-05-01Keywords
Amino Acid Sequence; Amino Acids; Bacteriophages; Molecular Sequence Data; MuramidaseLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions.Source
Proteins. 1992 May;13(1):38-40. Link to article on publisher's siteDOI
10.1002/prot.340130104Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32430PubMed ID
1594576Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/prot.340130104