Functional significance of conserved amino acid residues
| dc.contributor.author | Poteete, Anthony R. | |
| dc.contributor.author | Rennell, Dale | |
| dc.contributor.author | Bouvier, Suzanne E. | |
| dc.date | 2022-08-11T08:08:47.000 | |
| dc.date.accessioned | 2022-08-23T16:08:22Z | |
| dc.date.available | 2022-08-23T16:08:22Z | |
| dc.date.issued | 1992-05-01 | |
| dc.date.submitted | 2008-11-26 | |
| dc.identifier.citation | Proteins. 1992 May;13(1):38-40. <a href="http://dx.doi.org/10.1002/prot.340130104 ">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0887-3585 (Print) | |
| dc.identifier.doi | 10.1002/prot.340130104 | |
| dc.identifier.pmid | 1594576 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/32430 | |
| dc.description.abstract | A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1594576&dopt=Abstract">Link to article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1002/prot.340130104 | |
| dc.subject | Amino Acid Sequence; Amino Acids; Bacteriophages; Molecular Sequence Data; Muramidase | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | Functional significance of conserved amino acid residues | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Proteins | |
| dc.source.volume | 13 | |
| dc.source.issue | 1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1000 | |
| dc.identifier.contextkey | 673216 | |
| html.description.abstract | <p>A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions.</p> | |
| dc.identifier.submissionpath | gsbs_sp/1000 | |
| dc.contributor.department | Department of Molecular Genetics and Microbiology | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 38-40 |