• Login
    View Item 
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside Graduate School of Biomedical Sciences Scholarly Publications
    • View Item
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside Graduate School of Biomedical Sciences Scholarly Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Rigby, Mark R.
    Bortell, Rita
    Greiner, Dale L.
    Czech, Michael P.
    Klarlund, Jes K.
    Mordes, John P.
    Rossini, Aldo A.
    UMass Chan Affiliations
    Department of Medicine, Division of Endocrinology and Metabolism
    Department of Medicine, Diabetes Division
    Program in Molecular Medicine
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1996-10-01
    Keywords
    *ADP Ribose Transferases; Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Blotting, Western; DNA; Diabetes Mellitus, Type 1; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Lymphocyte Activation; Membrane Glycoproteins; Phosphorylation; Rats; Rats, Inbred BB; Rats, Inbred WF; Receptors, Interleukin-2; *Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine; src-Family Kinases
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.2337/diab.45.10.1419
    Abstract
    RT6 is a glycosyl-phosphatidylinositol-linked surface molecule present on most mature rat T-cells. RT6+ T-cells can prevent the expression of autoimmune diabetes in the BB rat, but the mechanism is unknown. Because cross-linking of other glycosyl-phosphatidylinositol-linked T-cell proteins is known to activate T-cells, we investigated the signaling properties of RT6. Antibody cross-linking of RT6 enhanced expression of the alpha subunit of the interleukin-2 (IL-2) receptor and potentiated the proliferation of rat T-cells cultured in the presence of phorbol ester plus recombinant IL-2 (rIL-2) and/or rIL-4. RT6 was found to coimmunoprecipitate with five tyrosine phosphorylated proteins including p60fyn and p56lck, members of the src tyrosine kinase family. Pretreatment of T-cells with phorbol ester increased the phosphorylation of proteins that coimmunoprecipitated with RT6, altered the electrophoretic mobility of several of these coimmunoprecipitated phosphoproteins, and increased the amount of p60fyn and p56lck coimmunoprecipitated with RT6. These data indicate that RT6-mediated signaling events may prime T-cells to respond to exogenous cytokines, suggesting a possible mechanism by which surface RT6 may influence T-cell function.
    Source

    Diabetes. 1996 Oct;45(10):1419-26.

    DOI
    10.2337/diab.45.10.1419
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32476
    PubMed ID
    8826980
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.2337/diab.45.10.1419
    Scopus Count
    Collections
    Morningside Graduate School of Biomedical Sciences Scholarly Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.