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dc.contributor.authorRobinson, Harriet L.
dc.contributor.authorFoster, Rosalinda Gram
dc.contributor.authorBlais, Bruce P.
dc.contributor.authorReinsch, Sigrid S.
dc.contributor.authorNewstein, Michael C.
dc.contributor.authorShank, Peter R.
dc.date2022-08-11T08:08:47.000
dc.date.accessioned2022-08-23T16:08:34Z
dc.date.available2022-08-23T16:08:34Z
dc.date.issued1992-10-01
dc.date.submitted2008-12-08
dc.identifier.citationVirology. 1992 Oct;190(2):866-71.
dc.identifier.issn0042-6822 (Print)
dc.identifier.pmid1325711
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32479
dc.description.abstractRecombinants of Rous-associated virus-0 and Br21 have been used to localize 5' viral sequences that affect the osteopetrotic potential of avian leukosis viruses. Rous-associated virus-0 is a benign subgroup E virus of endogenous origin that does not cause osteopetrosis. Br21 is a constructed subgroup E virus with high osteopetrotic potential. 5' sequences that affected osteopetrotic potential resided in an 834-bp region near the 5' LTR. Sequence analysis of this region revealed differences between Br21 and RAV-0 in the mRNA leader and codons for MA.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=1325711&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/0042-6822(92)90927-H
dc.subjectAnimals; Avian leukosis virus; Base Sequence; Chickens; Cloning, Molecular; Codon; DNA, Viral; Molecular Sequence Data; Osteopetrosis; Plasmids; RNA, Messenger; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Restriction Mapping
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.title5' avian leukosis virus sequences and osteopetrotic potential
dc.typeJournal Article
dc.source.journaltitleVirology
dc.source.volume190
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1048
dc.identifier.contextkey677768
html.description.abstract<p>Recombinants of Rous-associated virus-0 and Br21 have been used to localize 5' viral sequences that affect the osteopetrotic potential of avian leukosis viruses. Rous-associated virus-0 is a benign subgroup E virus of endogenous origin that does not cause osteopetrosis. Br21 is a constructed subgroup E virus with high osteopetrotic potential. 5' sequences that affected osteopetrotic potential resided in an 834-bp region near the 5' LTR. Sequence analysis of this region revealed differences between Br21 and RAV-0 in the mRNA leader and codons for MA.</p>
dc.identifier.submissionpathgsbs_sp/1048
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages866-71


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