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    Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae

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    Authors
    Blinder, Dmitry B.
    Jenness, Duane D.
    UMass Chan Affiliations
    Department of Molecular Genetics and Microbiology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1989-09-01
    Keywords
    Adaptation, Physiological; Cell Division; Peptides; Pheromones; Receptors, Cell Surface; Receptors, Mating Factor; *Receptors, Peptide; Saccharomyces cerevisiae; *Signal Transduction; *Transcription Factors
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC362432/
    Abstract
    alpha-Factor pheromone inhibits division of yeast a cells. After prolonged exposure to alpha-factor, the cells adapt to the stimulus and resume cell division. The sst2 mutation is known to inhibit adaptation. This report examines adaptation in scg1 (also designated gpa1) and STE4Hpl (Hpl indicates haploid lethal) mutants that exhibit constitutive activation of the pheromone response pathway. Recovery of the STE4Hpl mutant was blocked by the sst2-1 mutation, whereas recovery of the scg1-7 mutant was not completely blocked by sst2-1. These results indicate that both SST2-dependent and -independent mechanisms regulate postreceptor events in the pheromone response pathway. Down regulation of receptors in response to alpha-factor was independent of the signal that was generated in the scg1 mutant.
    Source

    Mol Cell Biol. 1989 Sep;9(9):3720-6.

    DOI
    10.1128/MCB.9.9.3720
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32481
    PubMed ID
    2550799
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1128/MCB.9.9.3720
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