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dc.contributor.authorBlinder, Dmitry B.
dc.contributor.authorJenness, Duane D.
dc.date2022-08-11T08:08:47.000
dc.date.accessioned2022-08-23T16:08:34Z
dc.date.available2022-08-23T16:08:34Z
dc.date.issued1989-09-01
dc.date.submitted2008-08-05
dc.identifier.citation<p>Mol Cell Biol. 1989 Sep;9(9):3720-6.</p>
dc.identifier.issn0270-7306 (Print)
dc.identifier.doi10.1128/MCB.9.9.3720
dc.identifier.pmid2550799
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32481
dc.description.abstractalpha-Factor pheromone inhibits division of yeast a cells. After prolonged exposure to alpha-factor, the cells adapt to the stimulus and resume cell division. The sst2 mutation is known to inhibit adaptation. This report examines adaptation in scg1 (also designated gpa1) and STE4Hpl (Hpl indicates haploid lethal) mutants that exhibit constitutive activation of the pheromone response pathway. Recovery of the STE4Hpl mutant was blocked by the sst2-1 mutation, whereas recovery of the scg1-7 mutant was not completely blocked by sst2-1. These results indicate that both SST2-dependent and -independent mechanisms regulate postreceptor events in the pheromone response pathway. Down regulation of receptors in response to alpha-factor was independent of the signal that was generated in the scg1 mutant.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2550799&dopt=Abstract ">Link to article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC362432/
dc.subjectAdaptation, Physiological; Cell Division; Peptides; Pheromones; Receptors, Cell Surface; Receptors, Mating Factor; *Receptors, Peptide; Saccharomyces cerevisiae; *Signal Transduction; *Transcription Factors
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleRegulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae
dc.typeJournal Article
dc.source.journaltitleMolecular and cellular biology
dc.source.volume9
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/105
dc.identifier.contextkey566359
html.description.abstract<p>alpha-Factor pheromone inhibits division of yeast a cells. After prolonged exposure to alpha-factor, the cells adapt to the stimulus and resume cell division. The sst2 mutation is known to inhibit adaptation. This report examines adaptation in scg1 (also designated gpa1) and STE4Hpl (Hpl indicates haploid lethal) mutants that exhibit constitutive activation of the pheromone response pathway. Recovery of the STE4Hpl mutant was blocked by the sst2-1 mutation, whereas recovery of the scg1-7 mutant was not completely blocked by sst2-1. These results indicate that both SST2-dependent and -independent mechanisms regulate postreceptor events in the pheromone response pathway. Down regulation of receptors in response to alpha-factor was independent of the signal that was generated in the scg1 mutant.</p>
dc.identifier.submissionpathgsbs_sp/105
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages3720-6


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