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    Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary

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    Authors
    Rush, Brandy L.
    Murad, Alejandro D.
    Emery, Patrick
    Giebultowicz, Jadwiga M.
    Student Authors
    Alejandro Murad
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Emery Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2006-07-26
    Keywords
    Animals; Animals, Genetically Modified; Biological Clocks; Circadian Rhythm; Drosophila Proteins; Drosophila melanogaster; Eye Proteins; Female; *Light; Nuclear Proteins; Ovarian Follicle; Receptors, G-Protein-Coupled
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://dx.doi.org/10.1177/0748730406290416
    Abstract
    The period (per) and timeless (tim) genes play a central role in the Drosophila circadian clock mechanism. PERIOD (PER) and TIMELESS (TIM) proteins periodically accumulate in the nuclei of pace-making cells in the fly brain and many cells in peripheral organs. In contrast, TIM and PER in the ovarian follicle cells remain cytoplasmic and do not show daily oscillations in their levels. Moreover, TIM is not light sensitive in the ovary, while it is highly sensitive to this input in circadian tissues. The mechanism underlying this intriguing difference is addressed here. It is demonstrated that the circadian photoreceptor CRYPTOCHROME (CRY) is not expressed in ovarian tissues. Remarkably, ectopic cry expression in the ovary is sufficient to cause degradation of TIM after exposure to light. In addition, PER levels are reduced in response to light when CRY is present, as observed in circadian cells. Hence, CRY is the key component of the light input pathway missing in the ovary. However, the factors regulating PER and TIM levels downstream of light/cry action appear to be present in this non-circadian organ.
    Source
    J Biol Rhythms. 2006 Aug;21(4):272-8. Link to article on publisher's site
    DOI
    10.1177/0748730406290416
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32487
    PubMed ID
    16864647
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1177/0748730406290416
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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