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dc.contributor.authorSairenji, Takeshi
dc.contributor.authorSullivan, John L.
dc.contributor.authorSakamoto, Kiyoshi
dc.contributor.authorSpiro, Robert Christopher
dc.contributor.authorKatayama, Isao
dc.contributor.authorHumphreys, Robert E.
dc.date2022-08-11T08:08:47.000
dc.date.accessioned2022-08-23T16:08:39Z
dc.date.available2022-08-23T16:08:39Z
dc.date.issued1985-01-01
dc.date.submitted2008-12-09
dc.identifier.citation<p>Cancer Res. 1985 Jan;45(1):411-5.</p>
dc.identifier.issn0008-5472 (Print)
dc.identifier.pmid2981160
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32501
dc.description.abstractImmune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested patients with values less than 2 S.D. below mean values for a group of 17 healthy adults: T-cell enumeration, seven of 13; mitogen responsiveness of phytohemagglutinin, 10 of 11; concanavalin A, 10 of 11; pokeweed mitogen, 10 of 11; B-cell responsiveness by anti-immunoglobulin immunobead stimulation, two of six; responsiveness to streptolysin O antigen, four of seven; mixed-lymphocyte reaction, six of seven; natural killer cell activity, six of eight. Specific immunity to Epstein-Barr virus was measured by complement-independent, antibody-mediated virus neutralization (mean index for HCL patients being 56% of control value) and complement-dependent virus neutralization (98% of control value). We concluded that, in spite of depressed levels of immune responses measured with general, cellular assays, functional levels of complement-dependent virus-neutralizing antibody were present in these HCL patients.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=2981160&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://cancerres.aacrjournals.org/content/45/1/411.long
dc.subjectAntibodies, Viral; Antibody Formation; Antigens, Viral; Complement System Proteins; *Cytotoxicity, Immunologic; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Killer Cells, Natural; Leukemia, Hairy Cell; *Lymphocyte Activation; Neutralization Tests
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleEpstein-Barr virus infections in hairy cell leukemia patients in the presence of complement-dependent neutralizing antibody
dc.typeJournal Article
dc.source.journaltitleCancer research
dc.source.volume45
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1069
dc.identifier.contextkey678836
html.description.abstract<p>Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested patients with values less than 2 S.D. below mean values for a group of 17 healthy adults: T-cell enumeration, seven of 13; mitogen responsiveness of phytohemagglutinin, 10 of 11; concanavalin A, 10 of 11; pokeweed mitogen, 10 of 11; B-cell responsiveness by anti-immunoglobulin immunobead stimulation, two of six; responsiveness to streptolysin O antigen, four of seven; mixed-lymphocyte reaction, six of seven; natural killer cell activity, six of eight. Specific immunity to Epstein-Barr virus was measured by complement-independent, antibody-mediated virus neutralization (mean index for HCL patients being 56% of control value) and complement-dependent virus neutralization (98% of control value). We concluded that, in spite of depressed levels of immune responses measured with general, cellular assays, functional levels of complement-dependent virus-neutralizing antibody were present in these HCL patients.</p>
dc.identifier.submissionpathgsbs_sp/1069
dc.source.pages411-5


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