Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
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AuthorsSelin, Liisa K.
Kraemer, Kristy A.
Pardoll, Drew M.
Schneck, Jonathan P.
Varga, Steven Michael
Santolucito, Paul A.
Pinto, Amelia K.
Welsh, Raymond M.
UMass Chan AffiliationsDepartment of Pathology
Graduate School of Biomedical Sciences
Document TypeJournal Article
KeywordsAnimals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Dimerization; Epitopes, T-Lymphocyte; H-2 Antigens; Immunodominant Epitopes; Immunoglobulin G; Immunologic Memory; Interferon Type II; Lymphocytic choriomeningitis virus; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muromegalovirus; Pichinde virus; Receptors, Antigen, T-Cell, alpha-beta; Staining and Labeling; Vaccinia virus; Virus Diseases
Medicine and Health Sciences
MetadataShow full item record
AbstractUsing a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.
Immunity. 1999 Dec;11(6):733-42.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/32520
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