Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
| dc.contributor.author | Selin, Liisa K. | |
| dc.contributor.author | Lin, Meei-Yun | |
| dc.contributor.author | Kraemer, Kristy A. | |
| dc.contributor.author | Pardoll, Drew M. | |
| dc.contributor.author | Schneck, Jonathan P. | |
| dc.contributor.author | Varga, Steven Michael | |
| dc.contributor.author | Santolucito, Paul A. | |
| dc.contributor.author | Pinto, Amelia K. | |
| dc.contributor.author | Welsh, Raymond M. | |
| dc.date | 2022-08-11T08:08:48.000 | |
| dc.date.accessioned | 2022-08-23T16:08:44Z | |
| dc.date.available | 2022-08-23T16:08:44Z | |
| dc.date.issued | 2000-01-08 | |
| dc.date.submitted | 2008-12-10 | |
| dc.identifier.citation | <p>Immunity. 1999 Dec;11(6):733-42.</p> | |
| dc.identifier.issn | 1074-7613 (Print) | |
| dc.identifier.doi | 10.1016/S1074-7613(00)80147-8 | |
| dc.identifier.pmid | 10626895 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/32520 | |
| dc.description.abstract | Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10626895&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://doi.org/10.1016/S1074-7613(00)80147-8 | |
| dc.subject | Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Dimerization; Epitopes, T-Lymphocyte; H-2 Antigens; Immunodominant Epitopes; Immunoglobulin G; Immunologic Memory; Interferon Type II; Lymphocytic choriomeningitis virus; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muromegalovirus; Pichinde virus; Receptors, Antigen, T-Cell, alpha-beta; Staining and Labeling; Vaccinia virus; Virus Diseases | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Immunity | |
| dc.source.volume | 11 | |
| dc.source.issue | 6 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1088 | |
| dc.identifier.contextkey | 679626 | |
| html.description.abstract | <p>Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.</p> | |
| dc.identifier.submissionpath | gsbs_sp/1088 | |
| dc.contributor.department | Department of Pathology | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 733-42 |
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