MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans
| dc.contributor.author | Shin, Tae Ho | |
| dc.contributor.author | Yasuda, Jun | |
| dc.contributor.author | Rocheleau, Christian Ernest | |
| dc.contributor.author | Lin, Rueyling | |
| dc.contributor.author | Soto, Martha C. | |
| dc.contributor.author | Bei, Yanxia | |
| dc.contributor.author | Davis, Roger J. | |
| dc.contributor.author | Mello, Craig C. | |
| dc.date | 2022-08-11T08:08:48.000 | |
| dc.date.accessioned | 2022-08-23T16:08:50Z | |
| dc.date.available | 2022-08-23T16:08:50Z | |
| dc.date.issued | 1999-09-17 | |
| dc.date.submitted | 2008-12-11 | |
| dc.identifier.citation | <p>Mol Cell. 1999 Aug;4(2):275-80.</p> | |
| dc.identifier.issn | 1097-2765 (Print) | |
| dc.identifier.doi | 10.1016/S1097-2765(00)80375-5 | |
| dc.identifier.pmid | 10488343 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/32544 | |
| dc.description.abstract | In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM-1/LIT-1 kinase is not yet known. Here we show that mom-4, a genetically defined effector of polarity signaling, encodes a MAP kinase kinase kinase-related protein that stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1. LIT-1 kinase activity requires a conserved residue analogous to an activating phosphorylation site in other kinases, including MAP kinases. These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10488343&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://doi.org/10.1016/S1097-2765(00)80375-5 | |
| dc.subject | Amino Acid Sequence; Animals; Body Patterning; Caenorhabditis elegans; *Caenorhabditis elegans Proteins; Conserved Sequence; Cytoskeletal Proteins; DNA-Binding Proteins; Embryo, Nonmammalian; Endoderm; Enzyme Activation; Helminth Proteins; High Mobility Group Proteins; Membrane Proteins; Molecular Sequence Data; Phosphorylation; Protein-Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Transcription Factors | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Molecular cell | |
| dc.source.volume | 4 | |
| dc.source.issue | 2 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1109 | |
| dc.identifier.contextkey | 680281 | |
| html.description.abstract | <p>In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM-1/LIT-1 kinase is not yet known. Here we show that mom-4, a genetically defined effector of polarity signaling, encodes a MAP kinase kinase kinase-related protein that stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1. LIT-1 kinase activity requires a conserved residue analogous to an activating phosphorylation site in other kinases, including MAP kinases. These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism.</p> | |
| dc.identifier.submissionpath | gsbs_sp/1109 | |
| dc.contributor.department | Program in Molecular Medicine | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 275-80 |
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