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Renin-angiotensin system in hypophysectomized rats. I. Control of blood pressure

dc.contributor.authorSimon, Claude Demosthene
dc.contributor.authorHoneyman, Thomas W.
dc.contributor.authorFray, John
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:08:53Z
dc.date.available2022-08-23T16:08:53Z
dc.date.issued1984-01-01
dc.date.submitted2008-12-11
dc.identifier.citation<p>Am J Physiol. 1984 Jan;246(1 Pt 1):E84-8.</p>
dc.identifier.issn0002-9513 (Print)
dc.identifier.doi10.1152/ajpendo.1984.246.1.E84
dc.identifier.pmid6364834
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32557
dc.description.abstractThe mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=6364834&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1152/ajpendo.1984.246.1.E84
dc.subjectAnimals; *Blood Pressure; Body Weight; Captopril; Growth Hormone; *Hypophysectomy; Kidney; Male; Rats; Renin; *Renin-Angiotensin System; Saralasin; Time Factors
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleRenin-angiotensin system in hypophysectomized rats. I. Control of blood pressure
dc.typeJournal Article
dc.source.journaltitleThe American journal of physiology
dc.source.volume246
dc.source.issue1 Pt 1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1120
dc.identifier.contextkey680293
html.description.abstract<p>The mechanisms whereby the pituitary gland maintains arterial pressure were investigated in rats. The arterial pressure in hypophysectomized rats was 30 mmHg below normal. Saralasin or captopril caused a further fall of 25 and 30 mmHg, respectively, suggesting that the renin-angiotensin system plays a role in blood pressure maintenance in hypophysectomized rats. Growth hormone administration to hypophysectomized rats increased the arterial pressure, but pretreatment with captopril prevented the effect. Plasma renin activity and basal renin secretion (in vitro) was normal in hypophysectomized rats despite a twofold greater renal renin content. Secretory responsiveness to isoproterenol and calcium omission was lower in hypophysectomized rats. It is concluded that the renin-angiotensin system plays a role in maintaining arterial blood pressure in hypophysectomized rats although the responsiveness of the system may be decreased.</p>
dc.identifier.submissionpathgsbs_sp/1120
dc.contributor.departmentDepartment of Physiology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pagesE84-8


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