The good, the bad and the ugly: the practical consequences of centrosome amplification
dc.contributor.author | Sluder, Greenfield | |
dc.contributor.author | Nordberg, Joshua J. | |
dc.date | 2022-08-11T08:08:48.000 | |
dc.date.accessioned | 2022-08-23T16:08:54Z | |
dc.date.available | 2022-08-23T16:08:54Z | |
dc.date.issued | 2004-03-24 | |
dc.date.submitted | 2009-01-12 | |
dc.identifier.citation | Curr Opin Cell Biol. 2004 Feb;16(1):49-54. <a href="http://dx.doi.org/10.1016/j.ceb.2003.11.006">Link to article on publisher's site</a> | |
dc.identifier.issn | 0955-0674 (Print) | |
dc.identifier.doi | 10.1016/j.ceb.2003.11.006 | |
dc.identifier.pmid | 15037304 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/32562 | |
dc.description.abstract | Centrosome amplification (the presence of more than two centrosomes at mitosis) is characteristic of many human cancers. Extra centrosomes can cause the assembly of multipolar spindles, which unequally distribute chromosomes to daughter cells; the resulting genetic imbalances may contribute to cellular transformation. However, this raises the question of how a population of cells with centrosome amplification can survive such chaotic mitoses without soon becoming non-viable as a result of chromosome loss. Recent observations indicate that a variety of mechanisms partially mute the practical consequences of centrosome amplification. Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15037304&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1016/j.ceb.2003.11.006 | |
dc.subject | Animals; Centrosome; Humans; Mitosis; Mitotic Spindle Apparatus; Neoplasms | |
dc.subject | Cell Biology | |
dc.subject | Life Sciences | |
dc.subject | Medicine and Health Sciences | |
dc.title | The good, the bad and the ugly: the practical consequences of centrosome amplification | |
dc.type | Journal Article | |
dc.source.journaltitle | Current opinion in cell biology | |
dc.source.volume | 16 | |
dc.source.issue | 1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1125 | |
dc.identifier.contextkey | 692116 | |
html.description.abstract | <p>Centrosome amplification (the presence of more than two centrosomes at mitosis) is characteristic of many human cancers. Extra centrosomes can cause the assembly of multipolar spindles, which unequally distribute chromosomes to daughter cells; the resulting genetic imbalances may contribute to cellular transformation. However, this raises the question of how a population of cells with centrosome amplification can survive such chaotic mitoses without soon becoming non-viable as a result of chromosome loss. Recent observations indicate that a variety of mechanisms partially mute the practical consequences of centrosome amplification. Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state.</p> | |
dc.identifier.submissionpath | gsbs_sp/1125 | |
dc.contributor.department | Department of Cell Biology | |
dc.source.pages | 49-54 | |
dc.contributor.student | Joshua J. Nordberg |