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dc.contributor.authorSluder, Greenfield
dc.contributor.authorNordberg, Joshua J.
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:08:54Z
dc.date.available2022-08-23T16:08:54Z
dc.date.issued2004-03-24
dc.date.submitted2009-01-12
dc.identifier.citationCurr Opin Cell Biol. 2004 Feb;16(1):49-54. <a href="http://dx.doi.org/10.1016/j.ceb.2003.11.006">Link to article on publisher's site</a>
dc.identifier.issn0955-0674 (Print)
dc.identifier.doi10.1016/j.ceb.2003.11.006
dc.identifier.pmid15037304
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32562
dc.description.abstractCentrosome amplification (the presence of more than two centrosomes at mitosis) is characteristic of many human cancers. Extra centrosomes can cause the assembly of multipolar spindles, which unequally distribute chromosomes to daughter cells; the resulting genetic imbalances may contribute to cellular transformation. However, this raises the question of how a population of cells with centrosome amplification can survive such chaotic mitoses without soon becoming non-viable as a result of chromosome loss. Recent observations indicate that a variety of mechanisms partially mute the practical consequences of centrosome amplification. Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15037304&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.ceb.2003.11.006
dc.subjectAnimals; Centrosome; Humans; Mitosis; Mitotic Spindle Apparatus; Neoplasms
dc.subjectCell Biology
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe good, the bad and the ugly: the practical consequences of centrosome amplification
dc.typeJournal Article
dc.source.journaltitleCurrent opinion in cell biology
dc.source.volume16
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1125
dc.identifier.contextkey692116
html.description.abstract<p>Centrosome amplification (the presence of more than two centrosomes at mitosis) is characteristic of many human cancers. Extra centrosomes can cause the assembly of multipolar spindles, which unequally distribute chromosomes to daughter cells; the resulting genetic imbalances may contribute to cellular transformation. However, this raises the question of how a population of cells with centrosome amplification can survive such chaotic mitoses without soon becoming non-viable as a result of chromosome loss. Recent observations indicate that a variety of mechanisms partially mute the practical consequences of centrosome amplification. Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state.</p>
dc.identifier.submissionpathgsbs_sp/1125
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages49-54
dc.contributor.studentJoshua J. Nordberg


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