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dc.contributor.authorSpiro, Robert Christopher
dc.contributor.authorAnsell, Jack E.
dc.contributor.authorKatayama, Isao
dc.contributor.authorMuralidharan, Kamala
dc.contributor.authorSullivan, John L.
dc.contributor.authorHumphreys, Robert E.
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:08:59Z
dc.date.available2022-08-23T16:08:59Z
dc.date.issued1981-11-01
dc.date.submitted2009-01-12
dc.identifier.citationAm J Hematol. 1981 Nov;11(3):261-70.
dc.identifier.issn0361-8609 (Print)
dc.identifier.pmid6947689
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32585
dc.description.abstractMorphological and biochemical differences were demonstrated between prolymphocytic leukemia cells obtained from the spleen and peripheral blood of one patient. Peripheral blood prolymphocytes had consistently smaller nuclear-cytoplasmic ratios than did splenic prolymphocytes. Percoll gradient-purified prolymphocytes from the spleen synthesized abundant amounts of some membrane proteins which were hardly expressed by peripheral blood prolymphocytes. Peripheral blood prolymphocytes did not change their expression of membrane proteins during three days in culture. These findings are consistent with the view that prolymphocytic leukemia cells from the spleen exist, on the average, at an earlier stage of differentiation than do circulating leukemic cells, and that peripheral blood leukemic cells are frozen at a specific phase of differentiation.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=6947689&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/ajh.2830110306
dc.subjectAged; Blood Cells; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin M; Leukemia, Lymphoid; Lymph Nodes; Male; Membrane Proteins; Molecular Weight; Spleen
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleDifferences in synthesis of membrane proteins by leukemic cells from spleen and peripheral blood indicate distinct subsets of malignant cells in a patient with prolymphocytic leukemia
dc.typeJournal Article
dc.source.journaltitleAmerican journal of hematology
dc.source.volume11
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1147
dc.identifier.contextkey692141
html.description.abstract<p>Morphological and biochemical differences were demonstrated between prolymphocytic leukemia cells obtained from the spleen and peripheral blood of one patient. Peripheral blood prolymphocytes had consistently smaller nuclear-cytoplasmic ratios than did splenic prolymphocytes. Percoll gradient-purified prolymphocytes from the spleen synthesized abundant amounts of some membrane proteins which were hardly expressed by peripheral blood prolymphocytes. Peripheral blood prolymphocytes did not change their expression of membrane proteins during three days in culture. These findings are consistent with the view that prolymphocytic leukemia cells from the spleen exist, on the average, at an earlier stage of differentiation than do circulating leukemic cells, and that peripheral blood leukemic cells are frozen at a specific phase of differentiation.</p>
dc.identifier.submissionpathgsbs_sp/1147
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Pharmacology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages261-70


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