Nuclear microenvironments support physiological control of gene expression
Authors
Stein, Gary S.Lian, Jane B.
Montecino, Martin A.
Stein, Janet L.
Van Wijnen, Andre J.
Javed, Amjad
Pratap, Jitesh
Choi, Je-Yong
Zaidi, Sayyed K.
Gutierrez, Soraya E.
Harrington, Kimberly Stacy
Shen, Jiali
Young, Daniel W.
Pockwinse, Shirwin M.
UMass Chan Affiliations
Department of Cell Biology and Cancer CenterGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2003-09-16Keywords
*Cell Nucleus; Chromatin; *Gene Expression Regulation; *Nuclear Matrix; Osteocalcin; Regulatory Sequences, Nucleic Acid; Transcription FactorsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.Source
Chromosome Res. 2003;11(5):527-36.
DOI
10.1023/A:1024943214431Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32601PubMed ID
12971727Related Resources
ae974a485f413a2113503eed53cd6c53
10.1023/A:1024943214431