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Nuclear microenvironments support physiological control of gene expression

dc.contributor.authorStein, Gary S.
dc.contributor.authorLian, Jane B.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorStein, Janet L.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorJaved, Amjad
dc.contributor.authorPratap, Jitesh
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorGutierrez, Soraya E.
dc.contributor.authorHarrington, Kimberly Stacy
dc.contributor.authorShen, Jiali
dc.contributor.authorYoung, Daniel W.
dc.contributor.authorPockwinse, Shirwin M.
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:09:03Z
dc.date.available2022-08-23T16:09:03Z
dc.date.issued2003-09-16
dc.date.submitted2009-01-13
dc.identifier.citation<p>Chromosome Res. 2003;11(5):527-36.</p>
dc.identifier.issn0967-3849 (Print)
dc.identifier.doi10.1023/A:1024943214431
dc.identifier.pmid12971727
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32601
dc.description.abstractThere is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=12971727&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1023/A:1024943214431
dc.subject*Cell Nucleus; Chromatin; *Gene Expression Regulation; *Nuclear Matrix; Osteocalcin; Regulatory Sequences, Nucleic Acid; Transcription Factors
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleNuclear microenvironments support physiological control of gene expression
dc.typeJournal Article
dc.source.journaltitleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
dc.source.volume11
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1164
dc.identifier.contextkey693070
html.description.abstract<p>There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.</p>
dc.identifier.submissionpathgsbs_sp/1164
dc.contributor.departmentDepartment of Cell Biology and Cancer Center
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages527-36


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