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    Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression

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    Authors
    Stein, Gary S.
    Lian, Jane B.
    Stein, Janet L.
    Van Wijnen, Andre J.
    Montecino, Martin A.
    Javed, Amjad
    Pratap, Jitesh
    Choi, Je-Yong
    Zaidi, Sayyed K.
    Gutierrez, Soraya E.
    Harrington, Kimberly Stacy
    Shen, Jiali
    Young, Daniel W.
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    UMass Chan Affiliations
    Department of Cell Biology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2003-01-10
    Keywords
    Animals; Bone and Bones; Cell Nucleus; Gene Expression Regulation; Humans; Protein Transport; Transcription Factors; *Transcription, Genetic; Vitamin D
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1002/jcb.10364
    Abstract
    The architecturally associated subnuclear organization of nucleic acids and cognate regulatory factors suggest functional interrelationships between nuclear structure and gene expression. Mechanisms that contribute to the spatial distribution of transcription factors within the three-dimensional context of nuclear architecture control the sorting of regulatory information as well as the assembly and activities of sites within the nucleus that support gene expression. Vitamin D control of gene expression serves as a paradigm for experimentally addressing mechanisms that govern the intranuclear targeting of regulatory factors to nuclear domains where transcription of developmental and tissue-specific genes occur. We will present an overview of molecular, cellular, genetic, and biochemical approaches that provide insight into the trafficking of regulatory factors that mediate vitamin D control of gene expression to transcriptionally active subnuclear sites. Examples will be presented that suggest modifications in the intranuclear targeting of transcription factors abrogate competency for vitamin D control of skeletal gene expression during development and fidelity of gene expression in tumor cells.
    Source
    J Cell Biochem. 2003 Feb 1;88(2):340-55. Link to article on publisher's site
    DOI
    10.1002/jcb.10364
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32608
    PubMed ID
    12520536
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcb.10364
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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