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    Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

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    Authors
    Stein, Gary S.
    Lian, Jane B.
    Van Wijnen, Andre J.
    Stein, Janet L.
    Javed, Amjad
    Montecino, Martin A.
    Zaidi, Sayyed K.
    Young, Daniel W.
    Choi, Je-Yong
    Gutierrez, Soraya E.
    Pockwinse, Shirwin M.
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    UMass Chan Affiliations
    Department of Cell Biology and Cancer Center
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2004-01-27
    Keywords
    Cell Cycle; *Cell Differentiation; *Cell Division; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; *Gene Expression Regulation; Models, Molecular; Nuclear Matrix; Nuclear Proteins; Osteocalcin; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcription Factors; *Transcription, Genetic
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1002/jcb.10777
    Abstract
    The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture.
    Source
    J Cell Biochem. 2004 Feb 1;91(2):287-302. Link to article on publisher's site
    DOI
    10.1002/jcb.10777
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32611
    PubMed ID
    14743389
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcb.10777
    Scopus Count
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    Morningside GSBS Scholarly Publications

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