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dc.contributor.authorStein, Gary S.
dc.contributor.authorLian, Jane B.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorStein, Janet L.
dc.contributor.authorJaved, Amjad
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorYoung, Daniel W.
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorGutierrez, Soraya E.
dc.contributor.authorPockwinse, Shirwin M.
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:09:06Z
dc.date.available2022-08-23T16:09:06Z
dc.date.issued2004-01-27
dc.date.submitted2009-01-13
dc.identifier.citationJ Cell Biochem. 2004 Feb 1;91(2):287-302. <a href="http://dx.doi.org/10.1002/jcb.10777">Link to article on publisher's site</a>
dc.identifier.issn0730-2312 (Print)
dc.identifier.doi10.1002/jcb.10777
dc.identifier.pmid14743389
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32611
dc.description.abstractThe temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14743389&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jcb.10777
dc.subjectCell Cycle; *Cell Differentiation; *Cell Division; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; *Gene Expression Regulation; Models, Molecular; Nuclear Matrix; Nuclear Proteins; Osteocalcin; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcription Factors; *Transcription, Genetic
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleNuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation
dc.typeJournal Article
dc.source.journaltitleJournal of cellular biochemistry
dc.source.volume91
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1173
dc.identifier.contextkey693080
html.description.abstract<p>The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture.</p>
dc.identifier.submissionpathgsbs_sp/1173
dc.contributor.departmentDepartment of Cell Biology and Cancer Center
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages287-302


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