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    Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

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    Authors
    Stein, Gary S.
    Lian, Jane B.
    Van Wijnen, Andre J.
    Stein, Janet L.
    Montecino, Martin A.
    Javed, Amjad
    Zaidi, Sayyed K.
    Young, Daniel W.
    Choi, Je-Yong
    Pockwinse, Shirwin M.
    UMass Chan Affiliations
    Department of Cell Biology and Cancer Center
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2004-05-25
    Keywords
    Bone and Bones; Cell Differentiation; Cell Division; Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 2 Subunit; Core Binding Factor Alpha 3 Subunit; Core Binding Factor alpha Subunits; DNA-Binding Proteins; Gene Expression Regulation; Neoplasm Proteins; Proto-Oncogene Proteins; Transcription Factors
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1038/sj.onc.1207676
    Abstract
    We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
    Source
    Oncogene. 2004 May 24;23(24):4315-29. Link to article on publisher's site
    DOI
    10.1038/sj.onc.1207676
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32612
    PubMed ID
    15156188
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.onc.1207676
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