Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
Authors
Stein, Gary S.Lian, Jane B.
Van Wijnen, Andre J.
Stein, Janet L.
Montecino, Martin A.
Javed, Amjad
Zaidi, Sayyed K.
Young, Daniel W.
Choi, Je-Yong
Pockwinse, Shirwin M.
UMass Chan Affiliations
Department of Cell Biology and Cancer CenterGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2004-05-25Keywords
Bone and Bones; Cell Differentiation; Cell Division; Core Binding Factor Alpha 1 Subunit; Core Binding Factor Alpha 2 Subunit; Core Binding Factor Alpha 3 Subunit; Core Binding Factor alpha Subunits; DNA-Binding Proteins; Gene Expression Regulation; Neoplasm Proteins; Proto-Oncogene Proteins; Transcription FactorsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.Source
Oncogene. 2004 May 24;23(24):4315-29. Link to article on publisher's siteDOI
10.1038/sj.onc.1207676Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32612PubMed ID
15156188Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/sj.onc.1207676
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