Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression
Document Type
Journal ArticlePublication Date
1996-08-01Keywords
Animals; Cell Cycle; Cell Nucleus; Gene Expression Regulation, Developmental; Humans; *Models, Genetic; Transcription, GeneticLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue-specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.Source
J Cell Biochem. 1996 Aug;62(2):198-209. Link to article on publisher's siteDOI
10.1002/(SICI)1097-4644(199608)62:2andlt;198::AID-JCB8andgt;3.0.CO;2-NPermanent Link to this Item
http://hdl.handle.net/20.500.14038/32613PubMed ID
8844400Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/(SICI)1097-4644(199608)62:2andlt;198::AID-JCB8andgt;3.0.CO;2-N