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    Histone gene transcription: a model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships

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    Authors
    Stein, Gary S.
    Stein, Janet L.
    Van Wijnen, Andre J.
    Lian, Jane B.
    UMass Chan Affiliations
    Department of Cell Biology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1994-04-01
    Keywords
    Animals; Base Sequence; Cell Cycle; Cell Differentiation; Cell Division; *Gene Expression Regulation; Histones; Humans; Molecular Sequence Data; Neoplasms; Promoter Regions (Genetics); *Transcription, Genetic
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1002/jcb.240540406
    Abstract
    Histone gene expression is restricted to the S-phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell cycle progression and the onset of differentiation. The H4 gene promoter is organized into a series of independent and overlapping regulatory elements which exhibit selective, phosphorylation-dependent interactions with multiple transactivation factors. The three-dimensional organization of the promoter and, in particular, its chromatin structure, nucleosome organization, and interactions with the nuclear matrix may contribute to interrelationships of activities at multiple promoter elements. Molecular mechanisms are discussed that may participate in the coordinate expression of S-phase-specific core and H1 histone genes, together with other genes functionally coupled with DNA replication.
    Source
    J Cell Biochem. 1994 Apr;54(4):393-404. Link to article on publisher's site
    DOI
    10.1002/jcb.240540406
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32617
    PubMed ID
    8014188
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcb.240540406
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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