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dc.contributor.authorStein, Gary S.
dc.contributor.authorStein, Janet L.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorLian, Jane B.
dc.date2022-08-11T08:08:48.000
dc.date.accessioned2022-08-23T16:09:08Z
dc.date.available2022-08-23T16:09:08Z
dc.date.issued1994-04-01
dc.date.submitted2009-01-13
dc.identifier.citationJ Cell Biochem. 1994 Apr;54(4):393-404. <a href="http://dx.doi.org/10.1002/jcb.240540406">Link to article on publisher's site</a>
dc.identifier.issn0730-2312 (Print)
dc.identifier.doi10.1002/jcb.240540406
dc.identifier.pmid8014188
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32617
dc.description.abstractHistone gene expression is restricted to the S-phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell cycle progression and the onset of differentiation. The H4 gene promoter is organized into a series of independent and overlapping regulatory elements which exhibit selective, phosphorylation-dependent interactions with multiple transactivation factors. The three-dimensional organization of the promoter and, in particular, its chromatin structure, nucleosome organization, and interactions with the nuclear matrix may contribute to interrelationships of activities at multiple promoter elements. Molecular mechanisms are discussed that may participate in the coordinate expression of S-phase-specific core and H1 histone genes, together with other genes functionally coupled with DNA replication.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8014188&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jcb.240540406
dc.subjectAnimals; Base Sequence; Cell Cycle; Cell Differentiation; Cell Division; *Gene Expression Regulation; Histones; Humans; Molecular Sequence Data; Neoplasms; Promoter Regions (Genetics); *Transcription, Genetic
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleHistone gene transcription: a model for responsiveness to an integrated series of regulatory signals mediating cell cycle control and proliferation/differentiation interrelationships
dc.typeJournal Article
dc.source.journaltitleJournal of cellular biochemistry
dc.source.volume54
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1179
dc.identifier.contextkey693086
html.description.abstract<p>Histone gene expression is restricted to the S-phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell cycle progression and the onset of differentiation. The H4 gene promoter is organized into a series of independent and overlapping regulatory elements which exhibit selective, phosphorylation-dependent interactions with multiple transactivation factors. The three-dimensional organization of the promoter and, in particular, its chromatin structure, nucleosome organization, and interactions with the nuclear matrix may contribute to interrelationships of activities at multiple promoter elements. Molecular mechanisms are discussed that may participate in the coordinate expression of S-phase-specific core and H1 histone genes, together with other genes functionally coupled with DNA replication.</p>
dc.identifier.submissionpathgsbs_sp/1179
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages393-404


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