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Functional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair

dc.contributor.authorStein, Gary S.
dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorBraastad, Corey D.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorStein, Janet L.
dc.contributor.authorLian, Jane B.
dc.contributor.authorJaved, Amjad
dc.date2022-08-11T08:08:49.000
dc.date.accessioned2022-08-23T16:09:12Z
dc.date.available2022-08-23T16:09:12Z
dc.date.issued2003-10-24
dc.date.submitted2009-01-13
dc.identifier.citation<p>Trends Cell Biol. 2003 Nov;13(11):584-92.</p>
dc.identifier.issn0962-8924 (Print)
dc.identifier.doi10.1016/j.tcb.2003.09.009
dc.identifier.pmid14573352
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32634
dc.description.abstractThe organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14573352&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/j.tcb.2003.09.009
dc.subjectAnimals; Apoptosis; Cell Nucleus; DNA Methylation; *DNA Repair; *DNA Replication; *Gene Expression Regulation; Humans; Models, Genetic; Nuclear Matrix
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleFunctional architecture of the nucleus: organizing the regulatory machinery for gene expression, replication and repair
dc.typeJournal Article
dc.source.journaltitleTrends in cell biology
dc.source.volume13
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1195
dc.identifier.contextkey693103
html.description.abstract<p>The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.</p>
dc.identifier.submissionpathgsbs_sp/1195
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages584-92


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