Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization
UMass Chan Affiliations
Program in Molecular Medicine and the Department of Molecular Genetics and MicrobiologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2001-01-09Keywords
Actins; Animals; Blastoderm; Cell Cycle Proteins; Centrosome; Colchicine; Cytochalasin D; Cytoskeleton; Drosophila; *Drosophila Proteins; Embryo, Nonmammalian; Insect Proteins; Interphase; Microtubules; Mitosis; Mutation; PolymersLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
In Drosophila syncytial blastoderm embryos, centrosomes specify the position of actin-based interphase caps and mitotic furrows. Mutations in the scrambled locus prevent assembly of mitotic furrows, but do not block actin cap formation. The scrambled gene encodes a protein that localizes to the mitotic furrows and centrosomes. Sced localization, actin reorganization from caps into mitotic furrows, and centrosome-coordinated assembly of actin caps are not blocked by microtubule disruption. Our results indicate that centrosomes may coordinate assembly of cortical actin caps through a microtubule-independent mechanism, and that Scrambled mediates a second microtubule-independent process that drives mitotic furrow assembly.Source
Nat Cell Biol. 2001 Jan;3(1):68-75. Link to article on publisher's siteDOI
10.1038/35050579Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32642PubMed ID
11146628Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/35050579