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    Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling

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    Authors
    Stoicov, Calin
    Saffari, Reza
    Cai, Xun
    Hasyagar, Chhaya
    Houghton, JeanMarie
    Student Authors
    Calin Stoicov
    UMass Chan Affiliations
    Department of Medicine
    Document Type
    Journal Article
    Publication Date
    2004-10-12
    Keywords
    Adenocarcinoma; Animals; Gastric Mucosa; Genetic Predisposition to Disease; Helicobacter Infections; Helicobacter pylori; Humans; Models, Biological; Signal Transduction; Stomach Neoplasms; Virulence
    Gastroenterology
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.gene.2004.07.023
    Abstract
    Gastric cancer remains the second most common cause of cancer-related mortality worldwide. The single most common cause of gastric cancer is chronic infection with the gram-negative microaerophilic spiral bacterium: Helicobacter pylori. Recent advances in this field have identified host factors which predispose to gastric cancer formation via modulation of the host immune response. In addition, recent work has explored bacterial virulence factors which may directly cause tissue damage, and lead to gastric carcinogenesis, as well as factors responsible for enhanced immune response. Environmental factors, long associated with a predilection for gastric cancer, are recognized as modifiers of key growth signalling pathways within the gastric mucosa and as such lead to growth alterations. This review focuses on exploring new advances in our understanding of bacterial factors, host genetic polymorphisms and the interaction between the bacterium and host at the level of the immune response and the regulation of proliferative and apoptotic signal transduction cascades. Modulation of the pivotal balance between cell growth and cell death leads to the formation of gastric adenocarcinoma.
    Source
    Gene. 2004 Oct 27;341:1-17. Link to article on publisher's site
    DOI
    10.1016/j.gene.2004.07.023
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32647
    PubMed ID
    15474284
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.gene.2004.07.023
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