The roles of DNA polymerases alpha and delta in DNA replication
| dc.contributor.author | Talanian, Robert Vincent | |
| dc.contributor.author | Wright, George E. | |
| dc.date | 2022-08-11T08:08:49.000 | |
| dc.date.accessioned | 2022-08-23T16:09:19Z | |
| dc.date.available | 2022-08-23T16:09:19Z | |
| dc.date.issued | 1990-01-01 | |
| dc.date.submitted | 2009-01-13 | |
| dc.identifier.citation | Pharmacol Ther. 1990;47(1):105-15. | |
| dc.identifier.issn | 0163-7258 (Print) | |
| dc.identifier.pmid | 2195552 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/32664 | |
| dc.description.abstract | The identities and precise roles of the DNA polymerase(s) involved in mammalian cell DNA replication are uncertain. Circumstantial evidence suggests that DNA polymerase alpha and at least one form of DNA polymerase delta, that which is stimulated by Proliferating Cell Nuclear Antigen, catalyze mammalian cell replicative DNA synthesis. Further, the in vitro properties of polymerases alpha and delta suggest a model for their coordinate action at the replication fork. The present paper summarizes the current status of DNA polymerases alpha and delta in DNA replication, and describes newly available approaches to the study of those enzymes. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=2195552&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1016/0163-7258(90)90047-6 | |
| dc.subject | Animals; DNA Polymerase II; DNA Polymerase III; DNA Replication; DNA-Directed DNA Polymerase | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | The roles of DNA polymerases alpha and delta in DNA replication | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Pharmacology and therapeutics | |
| dc.source.volume | 47 | |
| dc.source.issue | 1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1224 | |
| dc.identifier.contextkey | 693134 | |
| html.description.abstract | <p>The identities and precise roles of the DNA polymerase(s) involved in mammalian cell DNA replication are uncertain. Circumstantial evidence suggests that DNA polymerase alpha and at least one form of DNA polymerase delta, that which is stimulated by Proliferating Cell Nuclear Antigen, catalyze mammalian cell replicative DNA synthesis. Further, the in vitro properties of polymerases alpha and delta suggest a model for their coordinate action at the replication fork. The present paper summarizes the current status of DNA polymerases alpha and delta in DNA replication, and describes newly available approaches to the study of those enzymes.</p> | |
| dc.identifier.submissionpath | gsbs_sp/1224 | |
| dc.contributor.department | Department of Biochemistry and Molecular Pharmacology | |
| dc.contributor.department | Department of Pharmacology | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 105-15 |