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    Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children

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    Authors
    Tamaki, Hisashi
    Beaulieu, Brian L.
    Somasundaran, Mohan
    Sullivan, John L.
    UMass Chan Affiliations
    Department of Pediatrics
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1995-09-01
    Keywords
    Adult; Antigens, Viral; B-Lymphocytes; Base Sequence; Child, Preschool; DNA Primers; DNA, Viral; DNA-Binding Proteins; Disease Transmission, Vertical; Epstein-Barr Virus Nuclear Antigens; Female; HIV Seronegativity; HIV Seropositivity; Herpesvirus 4, Human; Histocompatibility Antigens Class I; Humans; Infant; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; T-Lymphocytes, Cytotoxic; Vaccinia virus
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://doi.org/10.1093/infdis/172.3.739
    Abstract
    Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte (CTL) responses were evaluated in 9 children aged 20-35 months. Autologous EBV-transformed B lymphoblastoid cell lines were used to restimulate EBV-specific memory CTL precursors in vitro. Recognition of individual EBV gene products by bulk CTL lines was evaluated by combining CTL lines with B cell blasts infected with recombinant vaccinia constructs expressing single latent genes. CTL lines from all 9 children recognized one or more EBV latent gene products. All children demonstrated CTL responses against one or more EBV nuclear antigen 3 proteins (EBNA3A, 3B, 3C), and EBNA3C was recognized most frequently. The striking similarity between EBV-specific CTL responses described here in young children and those reported for adults suggests that the EBNA3 family of proteins and latent membrane protein 2A should be considered for inclusion in candidate EBV vaccines.
    Source

    J Infect Dis. 1995 Sep;172(3):739-46.

    DOI
    10.1093/infdis/172.3.739
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32665
    PubMed ID
    7658067
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/172.3.739
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