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    Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation

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    Authors
    Tay, Joyce
    Hodgman, Rebecca
    Sarkissian, Madathia
    Richter, Joel D.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2003-06-20
    Keywords
    Animals; Antibody Specificity; Female; Genomic Imprinting; Meiosis; Mice; Mice, Knockout; Mutation; Oocytes; Ovary; Phosphoprotein Phosphatases; Phosphorylation; Polyadenylation; Prophase; Protein Biosynthesis; Protein-Serine-Threonine Kinases; RNA, Messenger; RNA-Binding Proteins; Threonine; Xenopus
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1101/gad.1071403
    Abstract
    CPEB is an mRNA-binding protein that stimulates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Thr 171 (species-dependent). Disruption of the CPEB gene in mice causes an arrest of oogenesis at embryonic day 16.5 (E16.5), when most oocytes are in pachytene of prophase I. Here, we show that CPEB undergoes Thr 171 phosphorylation at E16.5, but dephosphorylation at the E18.5, when most oocytes are entering diplotene. Although phosphorylation is mediated by the kinase aurora, the dephosphorylation is due to the phosphatase PP1. The temporal control of CPEB phosphorylation suggests a mechanism in which CPE-containing mRNA translation is stimulated at pachytene and metaphase I.
    Source
    Genes Dev. 2003 Jun 15;17(12):1457-62. Link to article on publisher's site
    DOI
    10.1101/gad.1071403
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32678
    PubMed ID
    12815066
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1101/gad.1071403
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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